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ME1 malic enzyme 1 [ Homo sapiens (human) ]

Gene ID: 4199, updated on 2-Nov-2024

Summary

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Official Symbol
ME1provided by HGNC
Official Full Name
malic enzyme 1provided by HGNC
Primary source
HGNC:HGNC:6983
See related
Ensembl:ENSG00000065833 MIM:154250; AllianceGenome:HGNC:6983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MES; HUMNDME
Summary
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues See more
Orthologs
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Genomic context

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See ME1 in Genome Data Viewer
Location:
6q14.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83210402..83431051, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84433644..84654257, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83920121..84140770, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene DOP1 leucine zipper like protein A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene MPRA-validated peak5928 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:84140986-84142185 Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91 Neighboring gene Sharpr-MPRA regulatory region 13924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17360

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sub-unit structure of soluble and mitochondrial malic enzyme: demonstration of human mitochondrial enzyme in human-mouse hybrids. Povey S, et al. Ann Hum Genet, 1975 Oct. PMID 1088824
  2. ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis. Lu YX, et al. Cancer Res, 2018 Apr 15. PMID 29654155
  3. ME1 promotes basal-like breast cancer progression and associates with poor prognosis. Liao R, et al. Sci Rep, 2018 Nov 13. PMID 30425310, Free PMC Article
  4. Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma. Nakashima C, et al. Cancer Sci, 2018 Jun. PMID 29601126, Free PMC Article
  5. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. Yao P, et al. J Biol Chem, 2017 Oct 13. PMID 28848047, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance.
    Title: Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance.
  2. Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?
    Title: Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?
  3. Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.
    Title: Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.
  4. miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1.
    Title: miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1.
  5. Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
    Title: Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
  6. In which ME1 transcripts are upregulated.
    Title: Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.
  7. A small molecule inhibitor of ME1 suppressed growth of human CRC cells in vitro, but had little effect on normal rat intestinal epithelial cells. Targeting of ME1 may add to the armentarium of therapies for cancers of the gastrointestinal tract.
    Title: Malic Enzyme 1 (ME1) is pro-oncogenic in Apc(Min/+) mice.
  8. ME1 promotes basal-like breast cancer progression and associates with poor prognosis
    Title: ME1 promotes basal-like breast cancer progression and associates with poor prognosis.
  9. results shed light on crucial roles of ME1-mediated production of NADPH in gastric cancer growth and metastasis
    Title: ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis.
  10. Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues.
    Title: Tumor-suppressing effects of microRNA-612 in bladder cancer cells by targeting malic enzyme 1 expression.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding TAS
Traceable Author Statement
more info
 PubMed 
enables NAD binding TAS
Traceable Author Statement
more info
 PubMed 
enables NADP binding TAS
Traceable Author Statement
more info
 PubMed 
enables electron transfer activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables malic enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malic enzyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxaloacetate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of NADP metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to carbohydrate TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to hormone ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADP-dependent malic enzyme
Names
Malic enzyme, cytoplasmic
NADP-ME
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
malic enzyme 1, NADP(+)-dependent, cytosolic
malic enzyme 1, soluble
pyruvic-malic carboxylase
NP_002386.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002395.6 → NP_002386.1  NADP-dependent malic enzyme

    See identical proteins and their annotated locations for NP_002386.1

    Status: REVIEWED

    Source sequence(s)
    AL049699, BC025246, DA520723, KF458214
    Consensus CDS
    CCDS34492.1
    UniProtKB/Swiss-Prot
    B4DZ70, P48163, Q16797, Q16855, Q53F72, Q5VWA2, Q9BWX8, Q9H1W3, Q9UIY4
    UniProtKB/TrEMBL
    A8K168
    Related
    ENSP00000358719.3, ENST00000369705.4
    Conserved Domains (3) summary
    cd05312
    Location:270 → 547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:11 → 551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79 → 260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    83210402..83431051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    84433644..84654257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48163.1 GenPept UniProtKB/Swiss-Prot:P48163

Gene LinkOut

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