abd-A abdominal A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: abd-Aprovided by FlyBase
Official Full Name: abdominal Aprovided by FlyBase
Primary source: FLYBASE:FBgn0000014
Locus tag: Dmel_CG10325
See related: AllianceGenome:FB:FBgn0000014
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: abd A; Abd A; abd-a; Abd-A; ABD-A; abda; abdA; Abda; AbdA; abd_a; BX-C; Cbxd; CG10325; Dmabda; DmabdA; Dmel\CG10325; Fab-3; Fab-4; Fub; Hab; iab; iab-2; iab-3; iab-4; iab-5; iab2; iab3; iab4; l(3)89Ec; Uab
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including genital disc development; heart development; and neuroblast differentiation. Located in nucleus and polytene chromosome band. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; imaginal disc; ventral intersegmental neurons; and visceral mesoderm derivative. Used to study leukemia. Orthologous to human HOXA6 (homeobox A6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 89E2-89E2; 3-59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16807214..16830049, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12632936..12655771, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Embryonic spatiotemporal expression pattern of Folded gastrulation suggests roles in multiple morphogenetic events and regulation by AbdA.
Title: Embryonic spatiotemporal expression pattern of Folded gastrulation suggests roles in multiple morphogenetic events and regulation by AbdA.
Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
Title: Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
Grh, AbdA, and Exd function together at multiple motifs on the apoptotic enhancer. Exd-Grh-Notch work with different Hox genes through region specific enhancers to pattern respective segments of larval central nervous system.
Title: Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS.
Identification of a two-step mechanism of Hox-driven transcription, with M1BP binding leading to Pol II recruitment followed by AbdA targeting, which results in a change in the chromatin landscape and enhanced transcription.
Title: The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.
We also observed that these functions of abd-A are required in its exclusive as well as the coexpression domain with that of Abd-B
Title: Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.
This "iab-8 RNA" produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only "in cis." Transcriptional interference with the abd-A promoter is the most likely mechanism
Title: abd-A regulation by the iab-8 noncoding RNA.
Abdominal-A uses both Pax2-dependent and Pax2-independent mechanisms to stimulate rhomboid Cis-regulatory-modules activity to induce proper oenocyte numbers.
Title: Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells.
The results uncover redundancy, interactivity, and multifunctionality of protein domains as salient features underlying overall AbdA protein activity
Title: Insights into Hox protein function from a large scale combinatorial analysis of protein domains.
Data show that the bithorax complex is an approximately 330kb genomic region that is responsible for directing the transcription of three homeotic (Hox) genes Ultrabithorax (Ubx), abdominal-A (abd-A) and Abdominal-B (Abd-B) during embryonic development.
Title: Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs.
Results suggest that the expression of cas is segment-specifically regulated negatively by Ubx and abdA genes, but positively by the AbdB gene.
Title: Drosophila castor is regulated negatively by the Ubx and abdA genes, but positively by the AbdB gene.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal vessel heart proper cell fate commitment	IEP Inferred from Expression Pattern more info	PubMed
involved_in dorsal vessel heart proper cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal vessel heart proper cell fate commitment	TAS Traceable Author Statement more info	PubMed
involved_in genital disc anterior/posterior pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in gonad development	TAS Traceable Author Statement more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in muscle cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oenocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oenocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome band	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: abdominal A

Names: Abdominal-A; CG10325-PA; CG10325-PB; CG10325-PC; CG10325-PD; Front-ultraabdominal; abd-A-PA; abd-A-PB; abd-A-PC; abd-A-PD; abdominalA; contrabithoraxoid; hyperabdominal; infra-abdominal 2; infra-abdominal 3; infra-abdominal 4; infraabdominal; ultraabdominal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16807214..16830049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260216.2 → NP_001247145.1 abdominal A, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247145.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIM9

Conserved Domains (2) summary

pfam00046
Location:142 → 194

Homeobox; Homeobox domain

pfam12407
Location:196 → 218

Abdominal-A; Homeobox protein
NM_057345.5 → NP_476693.1 abdominal A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476693.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIM9

Related

FBpp0082828

Conserved Domains (2) summary

pfam00046
Location:142 → 194

Homeobox; Homeobox domain

pfam12407
Location:196 → 218

Abdominal-A; Homeobox protein
NM_001170161.2 → NP_001163632.1 abdominal A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163632.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIM9

Conserved Domains (2) summary

pfam00046
Location:142 → 194

Homeobox; Homeobox domain

pfam12407
Location:196 → 218

Abdominal-A; Homeobox protein
NM_169733.5 → NP_732176.1 abdominal A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732176.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29555, Q5U161, Q9VER1

Related

FBpp0082829

Conserved Domains (2) summary

pfam00046
Location:402 → 454

Homeobox; Homeobox domain

pfam12407
Location:456 → 478

Abdominal-A; Homeobox protein