lbe ladybird early [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lbeprovided by FlyBase
Official Full Name: ladybird earlyprovided by FlyBase
Primary source: FLYBASE:FBgn0011278
Locus tag: Dmel_CG6545
See related: AllianceGenome:FB:FBgn0011278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6545; Dmel\CG6545; Hox11-D125; lb; Lb; Lbe; NK?
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including imaginal disc morphogenesis; myoblast fusion; and regulation of myoblast fusion. Located in nucleus. Is expressed in several structures, including anal pad primordium; cuboidal/columnar epithelium; segment; somatic muscle cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to several human genes including LBX1 (ladybird homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21441577..21446537, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17267299..17272259, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	HMP more info	PubMed