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pinta prolonged depolarization afterpotential (PDA) is not apparent [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42635, updated on 2-Nov-2024

Summary

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Official Symbol
pintaprovided by FlyBase
Official Full Name
prolonged depolarization afterpotential (PDA) is not apparentprovided by FlyBase
Primary source
FLYBASE:FBgn0038966
Locus tag
Dmel_CG13848
See related
AllianceGenome:FB:FBgn0038966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13848; CT33362; Dmel\CG13848; Pinta; PINTA; sec14
Summary
Enables retinoid binding activity. Involved in phototransduction and rhodopsin biosynthetic process. Is expressed in adult head; embryonic/larval garland cell; lch5 scolopidial dendritic cap cell; scolopale cell; and scolopidial dendritic cap cell. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See pinta in Genome Data Viewer
Location:
94A12-94A13; 3-74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22423316..22424929, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18249038..18250651, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nop56 Neighboring gene mob as tumor suppressor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors. Voolstra O, et al. J Biol Chem, 2010 Jan 15. PMID 19889630, Free PMC Article
  2. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Lai ZC, et al. Cell, 2005 Mar 11. PMID 15766530
  3. Both upstream and downstream intergenic regions are critical for the mob as tumor suppressor gene activity in Drosophila. Yang Y, et al. FEBS Lett, 2008 May 28. PMID 18472003
  4. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. Wang T, et al. J Neurosci, 2005 May 25. PMID 15917458, Free PMC Article
  5. Chromophore-Independent Roles of Opsin Apoproteins in Drosophila Mechanoreceptors. Katana R, et al. Curr Biol, 2019 Sep 9. PMID 31447373

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein
    Title: Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retinoid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhodopsin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
prolonged depolarization afterpotential (PDA) is not apparent
Names
CG13848-PA
CG13848-PB
Lyso-PA acyltransferase
pinta-PA
pinta-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22423316..22424929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300537.1 → NP_001287466.1  prolonged depolarization afterpotential (PDA) is not apparent, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287466.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VD09
    Conserved Domains (1) summary
    cd00170
    Location:87 → 240
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  2. NM_142785.2 → NP_651042.1  prolonged depolarization afterpotential (PDA) is not apparent, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VD09
    Related
    FBpp0083690
    Conserved Domains (1) summary
    cd00170
    Location:87 → 240
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VD09.1 Q9VD09

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