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MICA MHC class I polypeptide-related sequence A [ Homo sapiens (human) ]

Gene ID: 4276, discontinued on 10-Nov-2010

Summary

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Official Symbol
MICAprovided by HGNC
Official Full Name
MHC class I polypeptide-related sequence Aprovided by HGNC
Primary source
HGNC:HGNC:7090
See related
MIM:600169
Gene type
protein coding
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PERB11.1
Summary
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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Genomic context

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See MICA in Genome Data Viewer
Location:
6p21.33
Exon count:
6
Sequence:
Chromosome: 6; NC_000006.11 (31371371..31383090)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Clone Names

  • FLJ60820, MGC111087

General protein information

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Names
MHC class I polypeptide-related sequence A
HLA class I antigen
MHC class I chain-related protein A
stress inducible class I homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Build 37.1 (NOTE: not current)

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000006.11 Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

    Range
    31371371..31383090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000247.1 → NP_000238.1  

    See identical proteins and their annotated locations for NP_000238.1

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_2

Genomic

  1. NT_113891.2 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_2

    Range
    2884070..2895790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000247.1 → NP_000238.1  

    See identical proteins and their annotated locations for NP_000238.1

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_4

Genomic

  1. NT_167246.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_4

    Range
    2717805..2729520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000247.1 → NP_000238.1  

    See identical proteins and their annotated locations for NP_000238.1

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_6

Genomic

  1. NT_167248.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_6

    Range
    2664817..2676634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000247.1 → NP_000238.1  

    See identical proteins and their annotated locations for NP_000238.1

Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_7

Genomic

  1. NT_167249.1 Genome Reference Consortium Human Build 37 (GRCh37), ALT_REF_LOCI_7

    Range
    2705168..2716888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000247.1 → NP_000238.1  

    See identical proteins and their annotated locations for NP_000238.1

Alternate assembly (HuRef)

Genomic

  1. AC_000138.1 Alternate assembly (HuRef)

    Range
    31161772..31173490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000247.1 → NP_000238.1  

    See identical proteins and their annotated locations for NP_000238.1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29983.1 GenPept UniProtKB/Swiss-Prot:Q29983

Gene LinkOut

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