to takeout [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: toprovided by FlyBase
Official Full Name: takeoutprovided by FlyBase
Primary source: FLYBASE:FBgn0039298
Locus tag: Dmel_CG11853
See related: AllianceGenome:FB:FBgn0039298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11853; CT33074; Dmel\CG11853; JHBP9; Takeout; To
Summary: Involved in several processes, including adult feeding behavior; behavioral response to starvation; and male courtship behavior. Located in extracellular space. Is expressed in adult fat body; adult hindgut; adult pericerebral fat mass; and organism subdivision. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 96C7-96C7; 3-87 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25240180..25241668)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21065902..21067390)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There are 23 takeout family members in Drosophila melanogaster, and homologues of this family are distributed across insect species. Despite their sequence divergence takeout members from Aedes aegypti and Epiphas postvittana, as well as family members from D. melanogaster can substitute for takeout in courtship, demonstrating their functional conservation.
Title: High functional conservation of takeout family members in a courtship model system.
takeout-dependent longevity is associated with altered Juvenile Hormone signaling
Title: takeout-dependent longevity is associated with altered Juvenile Hormone signaling.
We show that a number of genes in the takeout gene family show male-biased expression in D. melanogaster, largely in non-reproductive tissues.
Title: Diversification of takeout, a male-biased gene family in Drosophila.
Data show that takeout levels are low in flies with reduced Pdp1epsilon and high in flies with increased amounts of Pdp1epsilon.
Title: The circadian output gene takeout is regulated by Pdp1epsilon.
takeout plays a central role as a feeding regulator and may act by modulating the circulating Juvenile Hormone level.
Title: Regulation of feeding behaviour and locomotor activity by takeout in Drosophila.
Drosophila Takeout gene expression varied with diurnal or circadian rhythms. These findings suggest that Apis mellifera GB19811 is not an ortholog of Takeout.
Title: Genes encoding putative Takeout/juvenile hormone binding proteins in the honeybee (Apis mellifera) and modulation by age and juvenile hormone of the takeout-like gene GB19811.
A loss-of-function mutation in the takeout gene reduces male courtship and synergizes with fruitless mutations, suggesting that takeout plays a redundant role with other fru-dependent factors involved in male mating behavior
Title: The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in feeding behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in male courtship behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	TAS Traceable Author Statement more info	PubMed
involved_in multicellular organismal reproductive process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	TAS Traceable Author Statement more info	PubMed
involved_in rhythmic behavior	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: takeout

Names: CG11853-PA; CG11853-PB; juvenile hormone binding protein 9; take-out; takeou; to-PA; to-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25240180..25241668

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300596.1 → NP_001287525.1 takeout, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287525.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MR66, Q9VBV2, Q9VBV3

UniProtKB/TrEMBL

A0A0B4LHM9

Conserved Domains (1) summary

pfam06585
Location:5 → 245

JHBP; Haemolymph juvenile hormone binding protein (JHBP)
NM_079773.2 → NP_524497.1 takeout, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524497.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MR66, Q9VBV2, Q9VBV3

UniProtKB/TrEMBL

A0A0B4LHM9

Related

FBpp0084185, FBtr0084810

Conserved Domains (1) summary

pfam06585
Location:5 → 245

JHBP; Haemolymph juvenile hormone binding protein (JHBP)