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Smim22 small integral membrane protein 22 [ Mus musculus (house mouse) ]

Gene ID: 432995, updated on 2-Nov-2024

Summary

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Official Symbol
Smim22provided by MGI
Official Full Name
small integral membrane protein 22provided by MGI
Primary source
MGI:MGI:3643379
See related
Ensembl:ENSMUSG00000096215 AllianceGenome:MGI:3643379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5480; EG432995
Summary
Predicted to be involved in several processes, including lipid droplet formation; positive regulation of cell migration; and regulation of actin cytoskeleton organization. Is expressed in embryo; embryo endoderm; and node. Orthologous to human SMIM22 (small integral membrane protein 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 69.0), duodenum adult (RPKM 56.5) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Smim22 in Genome Data Viewer
Location:
16 A1; 16 2.49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4825152..4826173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5007288..5008309)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene septin 12 Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene rogdi homolog Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) Neighboring gene STARR-positive B cell enhancer ABC_E1180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
small integral membrane protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253796.1 → NP_001240725.1  small integral membrane protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001240725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC163723, BB610432, CJ320043
    Consensus CDS
    CCDS57017.1
    UniProtKB/TrEMBL
    J3QP37
    Related
    ENSMUSP00000137083.2, ENSMUST00000178155.9
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 58
    DUF4713; Domain of unknown function (DUF4713)

  2. NM_001253797.1 → NP_001240726.1  small integral membrane protein 22 isoform 2

    See identical proteins and their annotated locations for NP_001240726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform 2 is shorter than isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC163723, CJ237462
    Consensus CDS
    CCDS70681.1
    UniProtKB/TrEMBL
    V9GXA9
    Related
    ENSMUSP00000139067.2, ENSMUST00000185147.8
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 58
    DUF4713; Domain of unknown function (DUF4713)

  3. NM_001253802.1 → NP_001240731.1  small integral membrane protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001240731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC163723, CJ043101
    Consensus CDS
    CCDS57017.1
    UniProtKB/TrEMBL
    J3QP37
    Related
    ENSMUSP00000139370.2, ENSMUST00000184439.8
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 58
    DUF4713; Domain of unknown function (DUF4713)

  4. NM_001253803.1 → NP_001240732.1  small integral membrane protein 22 isoform 2

    See identical proteins and their annotated locations for NP_001240732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC163723, AW985536
    Consensus CDS
    CCDS70681.1
    UniProtKB/TrEMBL
    V9GXA9
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 58
    DUF4713; Domain of unknown function (DUF4713)

RNA

  1. NR_045595.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC163723
    Related
    ENSMUST00000184256.7

  2. NR_045596.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC163723
    Related
    ENSMUST00000183381.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4825152..4826173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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