Mettl21c methyltransferase 21C, AARS1 lysine [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl21cprovided by MGI
Official Full Name: methyltransferase 21C, AARS1 lysineprovided by MGI
Primary source: MGI:MGI:3611450
See related: Ensembl:ENSMUSG00000047343 AllianceGenome:MGI:3611450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A530098C11Rik
Summary: Enables protein-lysine N-methyltransferase activity. Involved in protein methylation. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; hormone-mediated apoptotic signaling pathway; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in alimentary system; diaphragm; genitourinary system; skeletal muscle; and skin. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 1 C1.1; 1 23.52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (44048559..44081745, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (44009399..44042620, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL21C mediates autophagy and formation of slow-twitch muscle fibers in mice after exercise.
Title: METTL21C mediates autophagy and formation of slow-twitch muscle fibers in mice after exercise.
Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.
Title: Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.
METTL21C trimethylates p97 on the Lys315 residue and found that loss of this modification reduced p97 hexamer formation and ATPase activity in vivo.
Title: Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown.
Mettl21c knockdown modulated only the NF-kappaB signaling pathway.
Title: METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to dexamethasone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone-mediated apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in protein methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein methylation	ISO Inferred from Sequence Orthology more info
involved_in protein methylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-lysine methyltransferase METTL21C

Names: methyltransferase like 21C; methyltransferase-like protein 21C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013799.1 → NP_001013821.1 protein-lysine methyltransferase METTL21C

See identical proteins and their annotated locations for NP_001013821.1

Status: PROVISIONAL

Source sequence(s)

AK041301

Consensus CDS

CCDS14927.1

UniProtKB/Swiss-Prot

Q8BLU2

UniProtKB/TrEMBL

B2RVS5

Related

ENSMUSP00000061229.4, ENSMUST00000061421.4

Conserved Domains (1) summary

cl17173
Location:56 → 224

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

44048559..44081745 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496128.4 → XP_006496191.1 protein-lysine methyltransferase METTL21C isoform X1

See identical proteins and their annotated locations for XP_006496191.1

UniProtKB/Swiss-Prot

Q8BLU2

UniProtKB/TrEMBL

B2RVS5

Conserved Domains (1) summary

cl17173
Location:56 → 224

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006496126.5 → XP_006496189.1 protein-lysine methyltransferase METTL21C isoform X1

See identical proteins and their annotated locations for XP_006496189.1

UniProtKB/Swiss-Prot

Q8BLU2

UniProtKB/TrEMBL

B2RVS5

Conserved Domains (1) summary

cl17173
Location:56 → 224

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...