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Pusl1 pseudouridylate synthase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 433813, updated on 2-Nov-2024

Summary

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Official Symbol
Pusl1provided by MGI
Official Full Name
pseudouridylate synthase-like 1provided by MGI
Primary source
MGI:MGI:3047787
See related
Ensembl:ENSMUSG00000051557 AllianceGenome:MGI:3047787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810021I11Rik
Summary
Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Predicted to be located in mitochondrion. Orthologous to human PUSL1 (pseudouridine synthase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 20.1), adrenal adult (RPKM 18.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pusl1 in Genome Data Viewer
Location:
4 E2; 4 87.66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155973314..155976231, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155888857..155891858, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel, nonvoltage-gated 1, delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Busch JD, et al. Cell Rep, 2019 Nov 5. PMID 31693908, Free PMC Article
  2. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Max M, et al. Nat Genet, 2001 May. PMID 11326277
  3. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. Li X, et al. Mamm Genome, 2001 Jan. PMID 11178737, Free PMC Article
  4. A candidate taste receptor gene near a sweet taste locus. Montmayeur JP, et al. Nat Neurosci, 2001 May. PMID 11319557
  5. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.
    Title: MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA pseudouridine synthase-like 1
Names
tRNA pseudouridylate synthase-like 1
tRNA-uridine isomerase-like 1
NP_001028662.1
XP_030109505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033490.1 → NP_001028662.1  tRNA pseudouridine synthase-like 1

    See identical proteins and their annotated locations for NP_001028662.1

    Status: VALIDATED

    Source sequence(s)
    AL670236
    Consensus CDS
    CCDS51404.1
    UniProtKB/Swiss-Prot
    A2ADA5, Q3TVB3, Q3UAA3
    Related
    ENSMUSP00000095344.5, ENSMUST00000097737.5
    Conserved Domains (2) summary
    cd02570
    Location:18 → 284
    PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA
    PRK00021
    Location:13 → 284
    truA; tRNA pseudouridine synthase A; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155973314..155976231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253645.2 → XP_030109505.1  tRNA pseudouridine synthase-like 1 isoform X1

    Conserved Domains (1) summary
    cd02570
    Location:10 → 249
    PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA

RNA

  1. XR_390764.4 RNA Sequence

  2. XR_001784162.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ADA5.1 GenPept UniProtKB/Swiss-Prot:A2ADA5

Gene LinkOut

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