Rhox4c reproductive homeobox 4C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhox4cprovided by MGI
Official Full Name: reproductive homeobox 4Cprovided by MGI
Primary source: MGI:MGI:3613386
See related: Ensembl:ENSMUSG00000079635 AllianceGenome:MGI:3613386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rhox4b; Rhox4.3
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Annotation information: Note: This gene was previously named "Rhox4b" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.3" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4c. [07 Jan 2013]
Expression: Biased expression in placenta adult (RPKM 3.0), thymus adult (RPKM 0.4) and 1 other tissue See more
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Genomic context

Location:: X A3.3; X 21.78 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36661990..36666777)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37480337..37485124)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: reproductive homeobox 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039689.1 → NP_001034778.1 reproductive homeobox 4C

See identical proteins and their annotated locations for NP_001034778.1

Status: VALIDATED

Source sequence(s)

AJ972667

Consensus CDS

CCDS40933.1

UniProtKB/TrEMBL

B7ZWM1, Q2MDG1

Related

ENSMUSP00000110837.2, ENSMUST00000115183.2

Conserved Domains (2) summary

cd00086
Location:129 → 187

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

cl21455
Location:41 → 126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

36661990..36666777

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318539.2 → XP_017174028.1 reproductive homeobox 4C isoform X1

UniProtKB/TrEMBL

B7ZWM1

Conserved Domains (2) summary

cd00086
Location:129 → 186

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

cl38985
Location:41 → 126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006541510.3 → XP_006541573.1 reproductive homeobox 4C isoform X2

UniProtKB/TrEMBL

B7ZWB1

Conserved Domains (1) summary

cl38985
Location:41 → 126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases