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glct-6 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [ Caenorhabditis elegans ]

Gene ID: 4363062, updated on 2-Nov-2024

Summary

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Official Symbol
glct-6
Official Full Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Primary source
WormBase:WBGene00019546
Locus tag
CELE_W07G9.2
See related
AllianceGenome:WB:WBGene00019546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1) and B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glct-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (3784210..3794049)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Bestrophin homolog Neighboring gene Ephrin RBD domain-containing protein Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 3 Neighboring gene UDP-N-acetylglucosamine transferase subunit ALG14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
  2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
NP_001299964.1
  • Confirmed by transcript evidence
NP_001299965.1
  • Confirmed by transcript evidence
NP_001367955.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3784210..3794049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313035.3 → NP_001299964.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUF6
    Conserved Domains (1) summary
    pfam03360
    Location:125 → 330
    Glyco_transf_43; Glycosyltransferase family 43

  2. NM_001313036.3 → NP_001299965.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARJ9
    Conserved Domains (1) summary
    pfam03360
    Location:101 → 306
    Glyco_transf_43; Glycosyltransferase family 43

  3. NM_001380161.2 → NP_001367955.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SN66
    Conserved Domains (1) summary
    pfam03360
    Location:70 → 276
    Glyco_transf_43; Glycosyltransferase family 43
Nucleotide Protein
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