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NfI - Nuclear factor I

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic dorsal epidermis; embryonic ventral epidermis; larval muscle system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome; NFIA-related disorder; and Sotos syndrome 2. Orthologous to several human genes including NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa