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MXRA7 matrix remodeling associated 7 [ Homo sapiens (human) ]

Gene ID: 439921, updated on 5-Mar-2024

Summary

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Official Symbol
MXRA7provided by HGNC
Official Full Name
matrix remodeling associated 7provided by HGNC
Primary source
HGNC:HGNC:7541
See related
Ensembl:ENSG00000182534 AllianceGenome:HGNC:7541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 51.6), thyroid (RPKM 40.4) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76672551..76710965, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77569376..77607924, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74668633..74707047, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prothymosin alpha pseudogene 13 Neighboring gene RNA, U6 small nuclear 227, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74666855-74667812 Neighboring gene uncharacterized LOC105274304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74678511-74679057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74680151-74680695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74682678-74683473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74693235-74693788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74693789-74694342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74694343-74694895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74696218-74696722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74696723-74697227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74697733-74698236 Neighboring gene RNY4 pseudogene 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9024 Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74722561-74723190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74723821-74724449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74725107-74725737 Neighboring gene methyltransferase 23, arginine Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74732487-74733112 Neighboring gene serine and arginine rich splicing factor 2 Neighboring gene microRNA 636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH]. Ma KP, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2023 Feb. PMID 36765476
  2. Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model. Ning J, et al. Exp Dermatol, 2018 Sep. PMID 29781547
  3. Genetic loci for retinal arteriolar microcirculation. Sim X, et al. PLoS One, 2013. PMID 23776548, Free PMC Article
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
  5. Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. Ikeda KN, et al. J Biol Chem, 2019 Jul 26. PMID 31177093, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells.
    Title: Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells.
  2. [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH].
    Title: [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH].
  3. MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes.
    Title: Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic loci for retinal arteriolar microcirculation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41492, FLJ46603

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix-remodeling-associated protein 7
Names
matrix-remodelling associated 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008528.3 → NP_001008528.1  matrix-remodeling-associated protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001008528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC005837, AW297080, BC053983, CK300836
    Consensus CDS
    CCDS32745.1
    UniProtKB/Swiss-Prot
    P84157, Q0P5W3
    Related
    ENSP00000348050.2, ENST00000355797.7
    Conserved Domains (1) summary
    PHA03247
    Location:52 → 98
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001008529.3 → NP_001008529.1  matrix-remodeling-associated protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001008529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC005837, AK128460, AL046940, AW166143, BC053983
    Consensus CDS
    CCDS32746.1
    UniProtKB/Swiss-Prot
    P84157
    UniProtKB/TrEMBL
    Q6ZR64
    Related
    ENSP00000364176.1, ENST00000375036.6
    Conserved Domains (1) summary
    PHA03247
    Location:52 → 98
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001363769.2 → NP_001350698.1  matrix-remodeling-associated protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005837
    Consensus CDS
    CCDS86640.1
    UniProtKB/TrEMBL
    Q6ZR64
    Related
    ENSP00000465103.1, ENST00000592148.1

  4. NM_001387276.1 → NP_001374205.1  matrix-remodeling-associated protein 7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC005837

  5. NM_001387277.1 → NP_001374206.1  matrix-remodeling-associated protein 7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005837

  6. NM_001387278.1 → NP_001374207.1  matrix-remodeling-associated protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC005837

  7. NM_198530.4 → NP_940932.2  matrix-remodeling-associated protein 7 isoform 3

    See identical proteins and their annotated locations for NP_940932.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC005837, AL046940, BC053983
    Consensus CDS
    CCDS45786.1
    UniProtKB/Swiss-Prot
    P84157
    Related
    ENSP00000391466.1, ENST00000449428.7

RNA

  1. NR_130926.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005837

  2. NR_130927.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005837

  3. NR_130928.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005837

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    76672551..76710965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436104.1 → XP_047292060.1  matrix-remodeling-associated protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    77569376..77607924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316196.1 → XP_054172171.1  matrix-remodeling-associated protein 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84157.1 GenPept UniProtKB/Swiss-Prot:P84157

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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