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ZNF716 zinc finger protein 716 [ Homo sapiens (human) ]

Gene ID: 441234, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF716provided by HGNC
Official Full Name
zinc finger protein 716provided by HGNC
Primary source
HGNC:HGNC:32458
See related
Ensembl:ENSG00000182111 AllianceGenome:HGNC:32458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See ZNF716 in Genome Data Viewer
Location:
7p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (57450177..57473559)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (57693689..57717068)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (57509883..57533265)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 28 pseudogene Neighboring gene suppressor APC domain containing 2 pseudogene 2 Neighboring gene vomeronasal 1 receptor 29 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:57551016-57551994 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:57551995-57552973 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:57553020-57553651 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:57553652-57554282 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:57554283-57554914 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:57554915-57555545 Neighboring gene uncharacterized LOC105375300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. Simino J, et al. Front Genet, 2013. PMID 24376456, Free PMC Article
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article
  3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ46189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 716

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159279.1 → NP_001152751.1  zinc finger protein 716

    See identical proteins and their annotated locations for NP_001152751.1

    Status: VALIDATED

    Source sequence(s)
    AC092175, AK131575
    Consensus CDS
    CCDS55112.1
    UniProtKB/Swiss-Prot
    A6NP11
    Related
    ENSP00000394248.1, ENST00000420713.2
    Conserved Domains (6) summary
    smart00349
    Location:16 → 76
    KRAB; krueppel associated box
    COG5048
    Location:211 → 494
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298 → 318
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:16 → 55
    KRAB; KRAB box
    pfam13465
    Location:228 → 251
    zf-H2C2_2; Zinc-finger double domain
    pfam14353
    Location:353 → 398
    CpXC; CpXC protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    57450177..57473559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    57693689..57717068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NP11.4 GenPept UniProtKB/Swiss-Prot:A6NP11

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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