U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RFPL4B ret finger protein like 4B [ Homo sapiens (human) ]

Gene ID: 442247, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
RFPL4Bprovided by HGNC
Official Full Name
ret finger protein like 4Bprovided by HGNC
Primary source
HGNC:HGNC:33264
See related
Ensembl:ENSG00000251258 AllianceGenome:HGNC:33264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF211
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (112347330..112351294)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (113493205..113534708)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112668532..112672496)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LAMA4 antisense RNA 1 Neighboring gene uncharacterized LOC107986632 Neighboring gene PIN2 (TERF1) interacting telomerase inhibitor 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:112649857-112650442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:112683751-112684250 Neighboring gene ribosomal protein SA pseudogene 45 Neighboring gene keratin 18 pseudogene 65

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ret finger protein-like 4B
Names
RING finger protein 211

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013734.3 → NP_001013756.2  ret finger protein-like 4B

    See identical proteins and their annotated locations for NP_001013756.2

    Status: VALIDATED

    Source sequence(s)
    AK122906, AL365214, BC132796
    Consensus CDS
    CCDS34515.1
    UniProtKB/Swiss-Prot
    A2RU91, Q6ZWI9
    Related
    ENSP00000423391.1, ENST00000441065.3
    Conserved Domains (2) summary
    cd16564
    Location:10 → 53
    RING-HC_RNF222; RING finger, HC subclass, found in RING finger protein 222 (RNF222) and similar proteins
    cl02614
    Location:93 → 262
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    112347330..112351294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    113493205..113534708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355519.1 → XP_054211494.1  ret finger protein-like 4B isoform X1

    UniProtKB/Swiss-Prot
    A2RU91, Q6ZWI9

  2. XM_054355518.1 → XP_054211493.1  ret finger protein-like 4B isoform X1

    UniProtKB/Swiss-Prot
    A2RU91, Q6ZWI9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWI9.2 GenPept UniProtKB/Swiss-Prot:Q6ZWI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous