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IGFL4 IGF like family member 4 [ Homo sapiens (human) ]

Gene ID: 444882, updated on 28-Oct-2024

Summary

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Official Symbol
IGFL4provided by HGNC
Official Full Name
IGF like family member 4provided by HGNC
Primary source
HGNC:HGNC:32931
See related
Ensembl:ENSG00000204869 MIM:610547; AllianceGenome:HGNC:32931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable signaling receptor binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in skin (RPKM 2.1), brain (RPKM 0.4) and 1 other tissue See more
Orthologs
all
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Genomic context

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See IGFL4 in Genome Data Viewer
Location:
19q13.32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46039182..46077629, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48866645..48905083, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46542440..46580887, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46524919-46525804 Neighboring gene uncharacterized LOC105372421 Neighboring gene peptidoglycan recognition protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46535831-46536434 Neighboring gene IGF like family member 2 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene IGF like family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. Emtage P, et al. Genomics, 2006 Oct. PMID 16890402
  2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ39303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
insulin growth factor-like family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002923.3 → NP_001002923.1  insulin growth factor-like family member 4 precursor

    See identical proteins and their annotated locations for NP_001002923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC007785
    Consensus CDS
    CCDS33057.1
    UniProtKB/Swiss-Prot
    Q6B9Z1
    Related
    ENSP00000366926.1, ENST00000377697.2
    Conserved Domains (1) summary
    pfam14653
    Location:20 → 108
    IGFL; Insulin growth factor-like family

RNA

  1. NR_163175.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785

  2. NR_163176.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785

  3. NR_163177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785

  4. NR_169756.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785

  5. NR_169757.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007785

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46039182..46077629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438851.1 → XP_047294807.1  insulin growth factor-like family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6B9Z1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48866645..48905083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321053.1 → XP_054177028.1  insulin growth factor-like family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6B9Z1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_125344.1: Suppressed sequence

    Description
    NR_125344.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6B9Z1.1 GenPept UniProtKB/Swiss-Prot:Q6B9Z1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials