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MT1F metallothionein 1F [ Homo sapiens (human) ]

Gene ID: 4494, updated on 2-Nov-2024

Summary

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Official Symbol
MT1Fprovided by HGNC
Official Full Name
metallothionein 1Fprovided by HGNC
Primary source
HGNC:HGNC:7398
See related
Ensembl:ENSG00000198417 MIM:156352; AllianceGenome:HGNC:7398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1
Summary
Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thyroid (RPKM 263.0), kidney (RPKM 198.1) and 9 other tissues See more
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Genomic context

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See MT1F in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56657959..56659303)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62452925..62454269)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56691871..56693215)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56681377-56681944 Neighboring gene metallothionein 1C, pseudogene Neighboring gene metallothionein 1B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:56691221-56692194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56695770-56696644 Neighboring gene uncharacterized LOC101927536 Neighboring gene metallothionein 1G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Significance of metallothionein expression in breast myoepithelial cells. Jin R, et al. Cell Tissue Res, 2001 Feb. PMID 11291768
  2. The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma. Lu DD, et al. Yale J Biol Med, 2003. PMID 15369632, Free PMC Article
  3. Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA. Bylander JE, et al. Toxicol Lett, 1995 Apr. PMID 7762008
  4. Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. Huang YC, et al. Am J Respir Cell Mol Biol, 2009 Nov. PMID 19251948, Free PMC Article
  5. Immunohistochemical expression of metallothionein in pleomorphic adenoma of minor salivary glands: a role in the control of apoptosis? Miranda Viana Ade C, et al. Acta Histochem, 2013 Jul. PMID 23332881

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed.
    Title: Significance of the rapid increase in GSH levels in the protective response to cadmium exposure through phosphorylated Nrf2 signaling in Jurkat T-cells.
  2. Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma.
    Title: Immunohistochemical expression of metallothionein in pleomorphic adenoma of minor salivary glands: a role in the control of apoptosis?
  3. Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression.
    Title: Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2.
  4. findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy
    Title: Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients.
  5. MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue
    Title: Downregulation of metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue.
  6. This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression.
    Title: Metallothionein expression in colorectal cancer: relevance of different isoforms for tumor progression and patient survival.
  7. Studies provide the mechanistic properties of metal binding for metallothionein metallation.
    Title: The "magic numbers" of metallothionein.
  8. MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma.
    Title: Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma.
  9. MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts.
    Title: Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
  10. Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages.
    Title: Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Clone Names

  • MGC32732

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to zinc ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metallothionein-1F
Names
MT-1F
MT-IF
metallothionein 1F (functional)
metallothionein-IF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301272.2 → NP_001288201.1  metallothionein-1F isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a shorter isoform (2) with a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    BC029453, BM919862, W78077
    Consensus CDS
    CCDS76872.1
    UniProtKB/TrEMBL
    H3BRY8
    Related
    ENSP00000456462.1, ENST00000568475.1
    Conserved Domains (1) summary
    pfam00131
    Location:5 → 34
    Metallothio; Metallothionein

  2. NM_005949.4 → NP_005940.1  metallothionein-1F isoform 1

    See identical proteins and their annotated locations for NP_005940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BC029453, BQ939879
    Consensus CDS
    CCDS32456.1
    UniProtKB/Swiss-Prot
    P04733, Q93083, Q9UI97
    UniProtKB/TrEMBL
    Q8TE66
    Related
    ENSP00000334872.6, ENST00000334350.7
    Conserved Domains (1) summary
    pfam00131
    Location:1 → 60
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    56657959..56659303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62452925..62454269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04733.1 GenPept UniProtKB/Swiss-Prot:P04733

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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