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shi shibire [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45928, updated on 2-Nov-2024

Summary

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Official Symbol
shiprovided by FlyBase
Official Full Name
shibireprovided by FlyBase
Primary source
FLYBASE:FBgn0003392
Locus tag
Dmel_CG18102
See related
AllianceGenome:FB:FBgn0003392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.12; anon-WO0153538.13; anon-WO0153538.14; CG18102; dDyn; Ddyn; Ddyn3; Ddyn4; Dmel\CG18102; DNM3; dyn; Dyn; DYN; dynamin; Dynamin; l(1)shi; l(1)VII; Shi; shib; shibere; Shibire; shu; Vps1
Summary
Enables actin binding activity and microtubule binding activity. Involved in several processes, including epithelial cell migration; learning or memory; and synaptic vesicle cycle. Located in several cellular components, including mitotic spindle; sperm individualization complex; and synapse. Is active in neuromuscular junction. Is expressed in several structures, including adult brain; ganglia; germline cell; gonad; and head. Used to study collagen disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; developmental and epileptic encephalopathy 31A; developmental and epileptic encephalopathy 31B; and lethal congenital contracture syndrome. Orthologous to human DNM1 (dynamin 1); DNM2 (dynamin 2); and DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See shi in Genome Data Viewer
Location:
13F18-13F18; 1-52 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15892116..15906716)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15786149..15800749)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene membrane steroid binding protein Neighboring gene uncharacterized protein Neighboring gene Cyclin D Neighboring gene LDL receptor related protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acetylcholine synthesis and accumulation in the CNS of Drosophila larvae: analysis of shibirets, a mutant with a temperature-sensitive block in synaptic transmission. Wu CF, et al. J Neurochem, 1983 May. PMID 6300334
  2. MDN brain descending neurons coordinately activate backward and inhibit forward locomotion. Carreira-Rosario A, et al. Elife, 2018 Aug 2. PMID 30070205, Free PMC Article
  3. Developmental properties of Shibire: a pleiotropic mutation affecting larval and adult locomotion and development. Poodry CA, et al. Dev Biol, 1973 Jun. PMID 4208027
  4. Abolishment of Spontaneous Flight Turns in Visually Responsive Drosophila. Ferris BD, et al. Curr Biol, 2018 Jan 22. PMID 29337081, Free PMC Article
  5. The effects of increased temperature on electroretinograms of temperature-sensitive paralysis mutants of Drosophila melanogaster. Kelly LE, et al. Proc Natl Acad Sci U S A, 1974 Dec. PMID 4216025, Free PMC Article

See all (1000) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of Shi activity enhances extracellular Awd Drosophila cell lines.
    Title: Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein.
  2. results implicate mutant dynamin as an effective seizure suppressor, suggesting that targeting or limiting the availability of synaptic vesicles could be an effective and general method of controlling epilepsy disorders
    Title: Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
  3. These studies identify novel morphogenetic roles (i.e., tube closure and biased apical expansion), and expand upon established roles (i.e., cell intercalation and adhesion remodeling), for Dynamin in tubulogenesis.
    Title: Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary.
  4. Two GTPases, Rab5 and dynamin, are required for both the increased endocytic activity and compartmentalized Ca2+ transients in the dendritic pruning of Drosophila sensory neurons.
    Title: Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons.
  5. Dynamin is critically involved in the stabilization of Clathrin- and AP2-dependent endocytic pits.
    Title: Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval.
  6. indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror.
    Title: Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
  7. The shibire gene product, Dynamin, appears to be required for an immediate early response to ethanol that triggers a cellular response leading to rapid functional tolerance.
    Title: A role for dynamin in triggering ethanol tolerance.
  8. Data show that interfering with Dynamin- and Rab5-dependent endocytosis leads to a phenotype that is undistinguishable from that of the ninaE-null mutant.
    Title: Dynamin- and Rab5-dependent endocytosis is required to prevent Drosophila photoreceptor degeneration.
  9. A temperature sensitive shibire mutant was used to trap synaptic vesicles at the plasma membrane and extracted sterols from synaptic vesicles.
    Title: Vesicular sterols are essential for synaptic vesicle cycling.
  10. Pvr signaling is regulated by dynamin-mediated endocytosis that can be dominantly interfered with by Awd.
    Title: Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 15903202-15903367 mobile_element_type = transposon:INE-1{}2015

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bulk synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellularization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent endocytosis involved in vitellogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in olfactory learning IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proboscis extension reflex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin filament-based process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube architecture, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symbiont entry into host cell HMP PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in syncytial blastoderm mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm individualization complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
shibire
Names
CG18102-PA
CG18102-PB
CG18102-PC
CG18102-PE
CG18102-PF
CG18102-PG
CG18102-PH
CG18102-PI
CG18102-PJ
CG18102-PK
CG18102-PL
CG18102-PM
CG18102-PN
CG18102-PO
CG18102-PP
dynamin
shi-PA
shi-PB
shi-PC
shi-PE
shi-PF
shi-PG
shi-PH
shi-PI
shi-PJ
shi-PK
shi-PL
shi-PM
shi-PN
shi-PO
shi-PP
shibere
shibiri

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15892116..15906716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206742.1 → NP_996465.1  shibire, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27619, Q0KHS4, Q9VXM2
    UniProtKB/TrEMBL
    A4V4I8
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  2. NM_206745.3 → NP_996468.1  shibire, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996468.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4J0
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  3. NM_001272659.2 → NP_001259588.1  shibire, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHQ0
    Conserved Domains (8) summary
    smart00302
    Location:664 → 755
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 498
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 644
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:552 → 638
    PH; PH domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:761 → 846
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:758 → 819
    DUF4527; Protein of unknown function (DUF4527)

  4. NM_001298377.1 → NP_001285306.1  shibire, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285306.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JE15
    Conserved Domains (8) summary
    smart00302
    Location:649 → 740
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 498
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:514 → 619
    PH; PH domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:746 → 831
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:743 → 804
    DUF4527; Protein of unknown function (DUF4527)

  5. NM_001169295.1 → NP_001162766.1  shibire, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27619, Q0KHS4, Q9VXM2
    UniProtKB/TrEMBL
    A4V4I8
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  6. NM_167470.3 → NP_727910.1  shibire, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727910.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27619, Q0KHS4, Q9VXM2
    UniProtKB/TrEMBL
    A4V4I8
    Related
    FBpp0290810
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  7. NM_206743.2 → NP_996466.1  shibire, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996466.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27619, Q0KHS4, Q9VXM2
    UniProtKB/TrEMBL
    A4V4I8
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  8. NM_001272660.2 → NP_001259589.1  shibire, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJN9
    Conserved Domains (8) summary
    smart00302
    Location:649 → 740
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 498
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:514 → 619
    PH; PH domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:746 → 831
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:743 → 804
    DUF4527; Protein of unknown function (DUF4527)

  9. NM_001042814.2 → NP_001036279.1  shibire, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036279.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4J0
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  10. NM_001042813.2 → NP_001036278.1  shibire, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036278.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4J0
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  11. NM_001169297.2 → NP_001162768.1  shibire, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162768.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJA5
    Conserved Domains (8) summary
    smart00302
    Location:651 → 742
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 498
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:514 → 619
    PH; PH domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:748 → 833
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:745 → 806
    DUF4527; Protein of unknown function (DUF4527)

  12. NM_167471.5 → NP_727911.1  shibire, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727911.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4J0
    Related
    FBpp0073928
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  13. NM_206744.3 → NP_996467.1  shibire, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996467.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4J0
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)

  14. NM_001169296.1 → NP_001162767.1  shibire, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162767.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJA4
    Conserved Domains (8) summary
    smart00302
    Location:651 → 742
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 498
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:514 → 619
    PH; PH domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:748 → 833
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:745 → 806
    DUF4527; Protein of unknown function (DUF4527)

  15. NM_080114.4 → NP_524853.2  shibire, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524853.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4J0
    Related
    FBpp0073929
    Conserved Domains (7) summary
    smart00302
    Location:645 → 736
    GED; Dynamin GTPase effector domain
    smart00053
    Location:1 → 240
    DYNc; Dynamin, GTPase
    COG0699
    Location:73 → 735
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:512 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:212 → 498
    Dynamin_M; Dynamin central region
    pfam06346
    Location:742 → 827
    Drf_FH1; Formin Homology Region 1
    pfam15030
    Location:739 → 800
    DUF4527; Protein of unknown function (DUF4527)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V4I8 A4V4I8
A4V4J0 A4V4J0
E1JJA4 E1JJA4
E1JJA5 E1JJA5
M9PHQ0 M9PHQ0
M9PJN9 M9PJN9
P27619.2 P27619
X2JE15 X2JE15

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