shi shibire [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: shiprovided by FlyBase
Official Full Name: shibireprovided by FlyBase
Primary source: FLYBASE:FBgn0003392
Locus tag: Dmel_CG18102
See related: AllianceGenome:FB:FBgn0003392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.12; anon-WO0153538.13; anon-WO0153538.14; CG18102; dDyn; Ddyn; Ddyn3; Ddyn4; Dmel\CG18102; DNM3; dyn; Dyn; DYN; dynamin; Dynamin; l(1)shi; l(1)VII; Shi; shib; shibere; Shibire; shu; Vps1
Summary: Enables actin binding activity and microtubule binding activity. Involved in several processes, including endocytosis; germ cell development; and learning or memory. Located in several cellular components, including mitotic spindle; plasma membrane; and synapse. Part of sperm individualization complex. Is expressed in several structures, including adult heart; central nervous system; head; peripheral nervous system; and reproductive system. Used to study collagen disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; developmental and epileptic encephalopathy 31; and lethal congenital contracture syndrome. Orthologous to human DNM1 (dynamin 1); DNM2 (dynamin 2); and DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 13F18-13F18; 1-52 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15892116..15906716)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15786149..15800749)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulation of Shi activity enhances extracellular Awd Drosophila cell lines.
Title: Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein.
results implicate mutant dynamin as an effective seizure suppressor, suggesting that targeting or limiting the availability of synaptic vesicles could be an effective and general method of controlling epilepsy disorders
Title: Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
These studies identify novel morphogenetic roles (i.e., tube closure and biased apical expansion), and expand upon established roles (i.e., cell intercalation and adhesion remodeling), for Dynamin in tubulogenesis.
Title: Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary.
Two GTPases, Rab5 and dynamin, are required for both the increased endocytic activity and compartmentalized Ca2+ transients in the dendritic pruning of Drosophila sensory neurons.
Title: Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons.
Dynamin is critically involved in the stabilization of Clathrin- and AP2-dependent endocytic pits.
Title: Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval.
indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror.
Title: Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
The shibire gene product, Dynamin, appears to be required for an immediate early response to ethanol that triggers a cellular response leading to rapid functional tolerance.
Title: A role for dynamin in triggering ethanol tolerance.
Data show that interfering with Dynamin- and Rab5-dependent endocytosis leads to a phenotype that is undistinguishable from that of the ninaE-null mutant.
Title: Dynamin- and Rab5-dependent endocytosis is required to prevent Drosophila photoreceptor degeneration.
A temperature sensitive shibire mutant was used to trap synaptic vesicles at the plasma membrane and extracted sterols from synaptic vesicles.
Title: Vesicular sterols are essential for synaptic vesicle cycling.
Pvr signaling is regulated by dynamin-mediated endocytosis that can be dominantly interfered with by Awd.
Title: Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

mobile_element

Loc: 15903202-15903367 mobile_element_type = transposon:INE-1{}2015

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bulk synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis involved in vitellogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conditioned taste aversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IDA Inferred from Direct Assay more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proboscis extension reflex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin filament-based process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube architecture, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IDA Inferred from Direct Assay more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sperm individualization complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: shibire

Names: CG18102-PA; CG18102-PB; CG18102-PC; CG18102-PE; CG18102-PF; CG18102-PG; CG18102-PH; CG18102-PI; CG18102-PJ; CG18102-PK; CG18102-PL; CG18102-PM; CG18102-PN; CG18102-PO; CG18102-PP; dynamin; shi-PA; shi-PB; shi-PC; shi-PE; shi-PF; shi-PG; shi-PH; shi-PI; shi-PJ; shi-PK; shi-PL; shi-PM; shi-PN; shi-PO; shi-PP; shibere; shibiri

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15892116..15906716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206742.1 → NP_996465.1 shibire, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996465.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27619, Q0KHS4, Q9VXM2

UniProtKB/TrEMBL

A4V4I8

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_206745.3 → NP_996468.1 shibire, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996468.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4J0

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_001272659.2 → NP_001259588.1 shibire, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259588.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHQ0

Conserved Domains (8) summary

smart00302
Location:664 → 755

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 498

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 644

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam00169
Location:552 → 638

PH; PH domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:761 → 846

Drf_FH1; Formin Homology Region 1

pfam15030
Location:758 → 819

DUF4527; Protein of unknown function (DUF4527)
NM_001298377.1 → NP_001285306.1 shibire, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285306.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JE15

Conserved Domains (8) summary

smart00302
Location:649 → 740

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 498

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam00169
Location:514 → 619

PH; PH domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:746 → 831

Drf_FH1; Formin Homology Region 1

pfam15030
Location:743 → 804

DUF4527; Protein of unknown function (DUF4527)
NM_001169295.1 → NP_001162766.1 shibire, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162766.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27619, Q0KHS4, Q9VXM2

UniProtKB/TrEMBL

A4V4I8

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_167470.3 → NP_727910.1 shibire, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727910.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27619, Q0KHS4, Q9VXM2

UniProtKB/TrEMBL

A4V4I8

Related

FBpp0290810

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_206743.2 → NP_996466.1 shibire, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996466.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27619, Q0KHS4, Q9VXM2

UniProtKB/TrEMBL

A4V4I8

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_001272660.2 → NP_001259589.1 shibire, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259589.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJN9

Conserved Domains (8) summary

smart00302
Location:649 → 740

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 498

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam00169
Location:514 → 619

PH; PH domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:746 → 831

Drf_FH1; Formin Homology Region 1

pfam15030
Location:743 → 804

DUF4527; Protein of unknown function (DUF4527)
NM_001042814.2 → NP_001036279.1 shibire, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036279.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4J0

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_001042813.2 → NP_001036278.1 shibire, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036278.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4J0

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_001169297.2 → NP_001162768.1 shibire, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162768.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJA5

Conserved Domains (8) summary

smart00302
Location:651 → 742

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 498

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam00169
Location:514 → 619

PH; PH domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:748 → 833

Drf_FH1; Formin Homology Region 1

pfam15030
Location:745 → 806

DUF4527; Protein of unknown function (DUF4527)
NM_167471.5 → NP_727911.1 shibire, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727911.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4J0

Related

FBpp0073928

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_206744.3 → NP_996467.1 shibire, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996467.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4J0

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)
NM_001169296.1 → NP_001162767.1 shibire, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162767.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJA4

Conserved Domains (8) summary

smart00302
Location:651 → 742

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 498

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam00169
Location:514 → 619

PH; PH domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:748 → 833

Drf_FH1; Formin Homology Region 1

pfam15030
Location:745 → 806

DUF4527; Protein of unknown function (DUF4527)
NM_080114.4 → NP_524853.2 shibire, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524853.2

Status: REVIEWED

UniProtKB/TrEMBL

A4V4J0

Related

FBpp0073929

Conserved Domains (7) summary

smart00302
Location:645 → 736

GED; Dynamin GTPase effector domain

smart00053
Location:1 → 240

DYNc; Dynamin, GTPase

COG0699
Location:73 → 735

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:512 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:212 → 498

Dynamin_M; Dynamin central region

pfam06346
Location:742 → 827

Drf_FH1; Formin Homology Region 1

pfam15030
Location:739 → 800

DUF4527; Protein of unknown function (DUF4527)