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MYH10 myosin heavy chain 10 [ Homo sapiens (human) ]

Gene ID: 4628, updated on 7-Apr-2024

Summary

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Official Symbol
MYH10provided by HGNC
Official Full Name
myosin heavy chain 10provided by HGNC
Primary source
HGNC:HGNC:7568
See related
Ensembl:ENSG00000133026 MIM:160776; AllianceGenome:HGNC:7568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMMHCB; NMMHC-IIB
Summary
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues See more
Orthologs
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Genomic context

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See MYH10 in Genome Data Viewer
Location:
17p13.1
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8474212..8630725, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8380372..8536822, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8377530..8534043, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8285969-8286686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8286687-8287404 Neighboring gene Sharpr-MPRA regulatory region 12124 Neighboring gene ribosomal protein L26 Neighboring gene Sharpr-MPRA regulatory regions 4336 and 10869 Neighboring gene ring finger protein 222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8184 Neighboring gene MPRA-validated peak2716 silencer Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene MPRA-validated peak2717 silencer Neighboring gene Sharpr-MPRA regulatory region 9669 Neighboring gene uncharacterized LOC107987245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8390687-8391187 Neighboring gene Sharpr-MPRA regulatory region 1803 Neighboring gene uncharacterized LOC102724262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:8416542-8417741 Neighboring gene RNA, U7 small nuclear 43 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10362 Neighboring gene Sharpr-MPRA regulatory region 2377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11699 Neighboring gene ribosomal protein S26 pseudogene 53 Neighboring gene peptidylprolyl isomerase A pseudogene 52 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8532416-8533194 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8533195-8533972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8533973-8534750 Neighboring gene Sharpr-MPRA regulatory region 9864 Neighboring gene uncharacterized LOC105371525 Neighboring gene VISTA enhancer hs2548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8599868-8600378 Neighboring gene Sharpr-MPRA regulatory region 493 Neighboring gene uncharacterized LOC105371526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8642150-8642650 Neighboring gene coiled-coil domain containing 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling. Holtz AM, et al. Genet Med, 2022 Oct. PMID 35980381, Free PMC Article
  2. Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway. Jin Q, et al. J Cell Mol Med, 2021 Dec. PMID 34738311, Free PMC Article
  3. Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway. Wang Y, et al. Med Sci Monit, 2018 Dec 15. PMID 30552850, Free PMC Article
  4. Mammalian nonmuscle myosin II comes in three flavors. Shutova MS, et al. Biochem Biophys Res Commun, 2018 Nov 25. PMID 29550471, Free PMC Article
  5. Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia. Hong H, et al. Biochem Biophys Res Commun, 2015 May 22. PMID 25881509

See all (248) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.
    Title: Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.
  2. Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
    Title: Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
  3. MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.
    Title: MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.
  4. Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling.
    Title: Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling.
  5. Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway.
    Title: Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway.
  6. GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis.
    Title: GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis.
  7. The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
    Title: The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
  8. Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
    Title: Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
  9. survivin binds to non-muscle myosin II (NMII), regulating its filament assembly.
    Title: A direct interaction between survivin and myosin II is required for cytokinesis.
  10. Non-muscle myosin IIA (NMIIA) provides the mechanical tugging force necessary for cell-cell junction reinforcement and maintenance. Non-muscle myosin IIB (NMIIB) is involved in E-cadherin clustering, maintenance of a branched actin layer connecting E-cadherin complexes and perijunctional actin fibers in the biogenesis and integrity of adherens junctions.
    Title: Myosin II isoforms play distinct roles in adherens junction biogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2019-01-23)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with myosin, heavy chain 10, non-muscle (MYH10) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat The centripetal and lateral movements of the HIV-1 Tat protein transduction domain are linked to the integrity of myosin II-based actin contraction in HeLa cells PubMed
retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC134913, MGC134914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microfilament motor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actomyosin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myosin II filament IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin-10
Names
myosin heavy chain, nonmuscle type B
myosin, heavy chain 10, non-muscle
myosin, heavy polypeptide 10, non-muscle
nonmuscle myosin II heavy chain-B
nonmuscle myosin heavy chain IIB

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042305.2 RefSeqGene

    Range
    5037..161538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256012.3 → NP_001242941.1  myosin-10 isoform 1

    See identical proteins and their annotated locations for NP_001242941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC011061, AC025518, AC026130
    Consensus CDS
    CCDS58515.1
    UniProtKB/Swiss-Prot
    P35580
    UniProtKB/TrEMBL
    G1UI33
    Related
    ENSP00000353590.4, ENST00000360416.8
    Conserved Domains (3) summary
    cd14920
    Location:99 → 802
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:879 → 1959
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:33 → 72
    Myosin_N; Myosin N-terminal SH3-like domain

  2. NM_001256095.2 → NP_001243024.1  myosin-10 isoform 3

    See identical proteins and their annotated locations for NP_001243024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC011061, AC025518, AC026130
    Consensus CDS
    CCDS73984.1
    UniProtKB/Swiss-Prot
    P35580
    Related
    ENSP00000369315.5, ENST00000379980.8
    Conserved Domains (3) summary
    cd14920
    Location:99 → 780
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:857 → 1937
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:33 → 72
    Myosin_N; Myosin N-terminal SH3-like domain

  3. NM_001375266.1 → NP_001362195.1  myosin-10 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011061, AC025518, AC026130
    Consensus CDS
    CCDS92256.1
    UniProtKB/TrEMBL
    A0A8I5KZ38
    Related
    ENSP00000510471.1, ENST00000692526.1
    Conserved Domains (3) summary
    cd14920
    Location:99 → 781
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:858 → 1938
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:33 → 72
    Myosin_N; Myosin N-terminal SH3-like domain

  4. NM_005964.5 → NP_005955.3  myosin-10 isoform 2

    See identical proteins and their annotated locations for NP_005955.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC011061, AC025518, AC026130
    Consensus CDS
    CCDS11144.1
    UniProtKB/Swiss-Prot
    B2RWP9, D3DTS1, F8VTL3, P35580, Q12989, Q149N3, Q149N4, Q16087, Q4LE45, Q6PK16, Q9BWG0
    Related
    ENSP00000269243.4, ENST00000269243.8
    Conserved Domains (3) summary
    cd14920
    Location:99 → 771
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:848 → 1928
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:33 → 72
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8474212..8630725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8380372..8536822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35580.3 GenPept UniProtKB/Swiss-Prot:P35580

Gene LinkOut

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