DLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: DLA-DQA1
Gene description: major histocompatibility complex, class II, DQ alpha 1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: dqa 7; DLA-DQA
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	12	NC_051816.1 (2496829..2505376)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	12	NC_049233.1 (2375650..2382076)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	12	NC_049272.1 (2220046..2226466)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	12	NC_049753.1 (2301320..2307742)

Chromosome 12 - NC_051816.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

upstream regulatory regions (URRs) of the DLA-DRB, -DQA and -DQB genes were genotyped in 60 dogs
Title: A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
The haplotype DLADRB1* 01501/DQA1*00601/DQB1*00301 was significantly associated with chronic superficial keratitis (CSK) in German Shepherd dogs, and homozygosity of MHC class II increased risk for CSK.
Title: MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
Twenty-four dogs carried the DLA-DRB1*01201/DQA1*00401/DQB1*01303/DQB1*01701 haplotype, which carries two DQB1 alleles.
Title: Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing.
Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201
Title: Uveodermatologic (VKH-like) syndrome in American Akita dogs is associated with an increased frequency of DQA1*00201.
analysis of distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 among dog breeds
Title: Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptide antigen assembly with MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: major histocompatibility complex, class II, DQ alpha

Names: DLA class II antigen; MHC class II DLA DQA alpha chain; MHC class II antigen alpha chain; MHC class IIA antigen; dog leucocyte antigen DQA; integral membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011726.1 → NP_001011726.1 major histocompatibility complex, class II, DQ alpha precursor

See identical proteins and their annotated locations for NP_001011726.1

Status: PROVISIONAL

Source sequence(s)

U42407

UniProtKB/TrEMBL

A0A8C0T4C6, Q30410, Q30438

Conserved Domains (2) summary

pfam00993
Location:29 → 109

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

cd21008
Location:111 → 205

IgC1_MHC_II_alpha_HLA-DQ; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain of histocompatibility antigen (HLA) DQ and related proteins; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051816.1 Reference ROS_Cfam_1.0

Range

2496829..2505376

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038682718.1 → XP_038538646.1 major histocompatibility complex, class II, DQ alpha isoform X1

UniProtKB/TrEMBL

Q5W423

Conserved Domains (2) summary

pfam00993
Location:29 → 109

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

cd21008
Location:111 → 205

IgC1_MHC_II_alpha_HLA-DQ; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain of histocompatibility antigen (HLA) DQ and related proteins; member of the C1-set of Ig superfamily (IgSF) domains