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Abd-B Abdominal B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47763, updated on 2-Nov-2024

Summary

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Official Symbol
Abd-Bprovided by FlyBase
Official Full Name
Abdominal Bprovided by FlyBase
Primary source
FLYBASE:FBgn0000015
Locus tag
Dmel_CG11648
See related
AllianceGenome:FB:FBgn0000015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
9; Abd B; abd-B; Abd-b; ABD-B; Abd0B; abdB; Abdb; AbdB; ABDB; AbdB(CA)[[26]]; AbdB-I; AbdB-II; AbdBm; Adb-B; AdbB; bex; BX-C; CG10291; CG11648; DmAbdB; Dmel\CG11648; Droabdb; DROABDB; FAB; Fab-6; Fab-7; Fab-8; Fab6; Fab7; iab; IAB 5; iab-5; iab-6; iab-7; Iab-7; iab-8; iab5; IAB5; iab6; iab7; IAB7; iab8; IAB8; iab8.9; iab8/9; iab9; l(3)89Ed; Mc; Mcp; MCP; pH189; Sab; Tab; tuh-3; twig; Uab-5[Sab]
Summary
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including genital disc development; male pigmentation; and reproductive structure development. Located in nucleus and polytene chromosome band. Is expressed in several structures, including adult posterior abdominal ganglion neurons; anterior-posterior subdivision of organism; epithelium; genital disc; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in congenital vertical talus and radioulnar synostosis. Orthologous to several human genes including HOXA10 (homeobox A10) and HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Abd-B in Genome Data Viewer
Location:
89E4-89E5; 3-59 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16927212..16972236, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12752932..12797958, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:iab8 Neighboring gene MSA micropeptide Neighboring gene long non-coding RNA:iab4 Neighboring gene mir-iab-4 stem loop Neighboring gene mir-iab-8 stem loop Neighboring gene long non-coding RNA:CR43617 Neighboring gene long non-coding RNA:CR46267 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit d Neighboring gene alpha actinin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The tail segments are required by the performance but not the accomplishment of various modes of Drosophila larval locomotion. He Y, et al. Behav Brain Res, 2024 Aug 5. PMID 38825023
  2. The structure and function of the homeodomain. Scott MP, et al. Biochim Biophys Acta, 1989 Jul 28. PMID 2568852
  3. The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters. Zavortink M, et al. Genes Dev, 1989 Dec. PMID 2482824
  4. Identification and characterization of a parasegment specific regulatory element of the abdominal-B gene of Drosophila. Casanova J, et al. Cell, 1986 Nov 21. PMID 2877742
  5. Transabdominal, a dominant mutant of the Bithorax Complex, produces a sexually dimorphic segmental transformation in Drosophila. Celniker SE, et al. Genes Dev, 1987 Apr. PMID 3678820

See all (899) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated.
    Title: Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated.
  2. The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use.
    Title: The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use.
  3. Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
    Title: Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
  4. The capacity of Abdominal-B to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner
    Title: The Hox gene Abdominal-B uses Doublesex(F) as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system.
  5. complete reconstitution of bypass and blocking functions
    Title: Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex.
  6. Data report that the repression of Abd-B, in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages.
    Title: Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.
  7. iab-7 polycomb response element (PRE) functions as a component of the Fab-7 boundary. The boundary activity of the iab-7 PRE sequence depends upon a complex called the LBC, LBC is a multiprotein complex that contains at least three distinct DNA binding proteins, the GAGA factor (GAF), Clamp, and Mod(mdg4).
    Title: The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.
  8. analysis of blocking and bypass activities of the Fab-8 boundary in the Drosophila bithorax complex
    Title: Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.
  9. Abd-B is required in neurons during development for females to become highly receptive to male courtship. Abd-B neurons control pausing, a key aspect of female sexual receptivity, in response to male courtship.
    Title: Abdominal-B neurons control Drosophila virgin female receptivity.
  10. We also observed that these functions of abd-A are required in its exclusive as well as the coexpression domain with that of Abd-B
    Title: Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of genital disc primordium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in external genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in genital disc anterior/posterior pattern formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in genital disc sexually dimorphic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in gonadal mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived female genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male pigmentation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in midgut development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cardioblast cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of female receptivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of salivary gland boundary specification TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of striated muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in segment specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in specification of segmental identity, abdomen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spiracle morphogenesis, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome band IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
abdominal B
Names
Abd-B-PA
Abd-B-PB
Abd-B-PC
Abd-B-PD
Abd-B-PE
Abd-B-PF
Abd-B-PG
Abd-B-PH
Abd-B-PI
Abd-B-PJ
Abdominal-B
AbdominalB
CG11648-PA
CG11648-PB
CG11648-PC
CG11648-PD
CG11648-PE
CG11648-PF
CG11648-PG
CG11648-PH
CG11648-PI
CG11648-PJ
abdominal-A
corset
infra-abdominal 5
infra-abdominal 6
infra-abdominal 7
infra-abdominal 8
infra-abdominal 9
infraabdominal
infraabdominal-8.9
male chauvinist pigmentation
microcephalus
miscadastral pigmentation
superabdominal
transabdominal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16927212..16972236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206498.2 → NP_996220.1  abdominal B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996220.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V304
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  2. NM_001316545.1 → NP_001303474.1  abdominal B, isoform I [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V304
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  3. NM_001316543.1 → NP_001303472.1  abdominal B, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09087, Q9VEQ8, Q9VEQ9
    UniProtKB/TrEMBL
    A0A126GUV3
    Conserved Domains (1) summary
    pfam00046
    Location:390 → 443
    Homeobox; Homeobox domain

  4. NM_001316542.1 → NP_001303471.1  abdominal B, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V304
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  5. NM_169735.2 → NP_732180.1  abdominal B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V304
    Related
    FBpp0082823
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  6. NM_142320.2 → NP_650577.1  abdominal B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650577.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V304
    Related
    FBpp0082824
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  7. NM_169736.2 → NP_732181.1  abdominal B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732181.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V304
    Related
    FBpp0082825
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  8. NM_001275719.2 → NP_001262648.1  abdominal B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGT1
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  9. NM_001316544.1 → NP_001303473.1  abdominal B, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUV9
    Conserved Domains (1) summary
    pfam00046
    Location:167 → 220
    Homeobox; Homeobox domain

  10. NM_080157.3 → NP_524896.2  abdominal B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524896.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09087, Q9VEQ8, Q9VEQ9
    UniProtKB/TrEMBL
    A0A126GUV3
    Related
    FBpp0082826
    Conserved Domains (1) summary
    pfam00046
    Location:390 → 443
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGT1 A0A0B4KGT1
A0A126GUV3 A0A126GUV3
A0A126GUV9 A0A126GUV9
A4V304 A4V304
P09087.3 P09087
Q86P38 Q86P38
Q9VEQ7 Q9VEQ7
V9H1H6 V9H1H6

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