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SCN3A sodium voltage-gated channel alpha subunit 3 [ Canis lupus familiaris (dog) ]

Gene ID: 478772, updated on 17-Aug-2024

Summary

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Official Symbol
SCN3Aprovided by VGNC
Official Full Name
sodium voltage-gated channel alpha subunit 3provided by VGNC
Primary source
VGNC:VGNC:45918
See related
Ensembl:ENSCAFG00845015933
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (10431868..10536904, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (10443366..10548111, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (10598953..10703719, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (10504943..10609699, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (10485818..10590745, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152220 Neighboring gene solute carrier family 38 member 11 Neighboring gene uncharacterized LOC111094251 Neighboring gene acyl-CoA-binding protein-like Neighboring gene uncharacterized LOC102152710 Neighboring gene ral guanine nucleotide dissociation stimulator-like Neighboring gene sodium voltage-gated channel alpha subunit 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 3 subunit alpha
Names
sodium channel, voltage-gated, type III, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    10431868..10536904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446924.1 → XP_038302852.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04
    Related
    ENSCAFP00845022337.1, ENSCAFT00845028395.1
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038446923.1 → XP_038302851.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04
    Related
    ENSCAFP00845022376.1, ENSCAFT00845028444.1
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038446926.1 → XP_038302854.1  sodium channel protein type 3 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1419 → 1471
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1155 → 1427
    Ion_trans; Ion transport protein
    pfam06512
    Location:948 → 1150
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1847 → 1888
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 660
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1743 → 1790
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038446925.1 → XP_038302853.1  sodium channel protein type 3 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0NX04
    Related
    ENSCAFP00845022421.1, ENSCAFT00845028502.1
    Conserved Domains (6) summary
    cd13433
    Location:1451 → 1503
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1187 → 1459
    Ion_trans; Ion transport protein
    pfam06512
    Location:980 → 1182
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1879 → 1920
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 692
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1775 → 1822
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038446922.1 → XP_038302850.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_038446927.1 → XP_038302855.1  sodium channel protein type 3 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8C0RNQ0
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    10504943..10609699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520999.1 → XP_038376927.1  sodium channel protein type 3 subunit alpha isoform X1

  2. XM_038520998.1 → XP_038376926.1  sodium channel protein type 3 subunit alpha isoform X1

  3. XM_038521001.1 → XP_038376929.1  sodium channel protein type 3 subunit alpha isoform X3

  4. XM_038521000.1 → XP_038376928.1  sodium channel protein type 3 subunit alpha isoform X2

  5. XM_038520997.1 → XP_038376925.1  sodium channel protein type 3 subunit alpha isoform X1

  6. XM_038521003.1 → XP_038376931.1  sodium channel protein type 3 subunit alpha isoform X4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    10485818..10590745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649110.1 → XP_038505038.1  sodium channel protein type 3 subunit alpha isoform X1

  2. XM_038649109.1 → XP_038505037.1  sodium channel protein type 3 subunit alpha isoform X1

  3. XM_038649112.1 → XP_038505040.1  sodium channel protein type 3 subunit alpha isoform X3

  4. XM_038649111.1 → XP_038505039.1  sodium channel protein type 3 subunit alpha isoform X2

  5. XM_038649108.1 → XP_038505036.1  sodium channel protein type 3 subunit alpha isoform X1

  6. XM_038649114.1 → XP_038505042.1  sodium channel protein type 3 subunit alpha isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    10598953..10703719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584693.1 → XP_038440621.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04

  2. XM_038584692.1 → XP_038440620.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04

  3. XM_038584695.1 → XP_038440623.1  sodium channel protein type 3 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0NX04

  4. XM_038584694.1 → XP_038440622.1  sodium channel protein type 3 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0NX04

  5. XM_038584691.1 → XP_038440619.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04

  6. XM_038584696.1 → XP_038440624.1  sodium channel protein type 3 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8C0RNQ0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10443366..10548111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038463386.1 → XP_038319314.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_038463385.1 → XP_038319313.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_038463388.1 → XP_038319316.1  sodium channel protein type 3 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1419 → 1471
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1155 → 1427
    Ion_trans; Ion transport protein
    pfam06512
    Location:948 → 1150
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1847 → 1888
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 660
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1743 → 1790
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_038463387.1 → XP_038319315.1  sodium channel protein type 3 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1451 → 1503
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1187 → 1459
    Ion_trans; Ion transport protein
    pfam06512
    Location:980 → 1182
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1879 → 1920
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 692
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1775 → 1822
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_038463384.1 → XP_038319312.1  sodium channel protein type 3 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0NX04
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_022414727.2 → XP_022270435.2  sodium channel protein type 3 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8C0RNQ0
    Conserved Domains (6) summary
    cd13433
    Location:1468 → 1520
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1476
    Ion_trans; Ion transport protein
    pfam06512
    Location:997 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam07989
    Location:1896 → 1937
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam11933
    Location:512 → 709
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1792 → 1839
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
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