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MDV057 envelope glycoprotein C [ Gallid alphaherpesvirus 2 ]

Gene ID: 4811518, updated on 18-Aug-2023

Summary

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Gene symbol
MDV057
Gene description
envelope glycoprotein C
Locus tag
MD5V_057
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallid alphaherpesvirus 2 (strain: Md5, common: Marek's disease virus type 1, acronym: GaHV-2, acronym: MDV-1, nat-host: Gallus gallus)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus
Old locus tag
GaHV2Md5_gp057
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Genomic context

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Sequence:
NC_002229.3 (102164..103827)

NC_002229.3Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase subunit 1 Neighboring gene ribonucleotide reductase subunit 2 Neighboring gene tegument host shutoff protein Neighboring gene DNA polymerase processivity subunit Neighboring gene envelope protein UL43 Neighboring gene membrane protein UL45 Neighboring gene tegument protein VP11/12 Neighboring gene tegument protein VP13/14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002229.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Marek's disease alphaherpesvirus (MDV) RLORF4 is not required for expression of glycoprotein C and interindividual spread. Vega-Rodriguez W, et al. Virology, 2019 Aug. PMID 31226665
  2. Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential. Jarosinski KW, et al. J Virol, 2010 Aug. PMID 20484497, Free PMC Article
  3. The genome of a very virulent Marek's disease virus. Tulman ER, et al. J Virol, 2000 Sep. PMID 10933706, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RLORF4 does not regulate gC expression and is not required for horizontal transmission.
    Title: Marek's disease alphaherpesvirus (MDV) RLORF4 is not required for expression of glycoprotein C and interindividual spread.
  2. US2-negative mutants transmitted horizontally, eliminating US2 as being essential for the process. In contrast, the absence of gC or mutating the UL13 kinase activity abolished horizontal spread of Marek's disease virus between chickens.
    Title: Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential.
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General gene information

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Homology

regulatory

  • Loc: 103695-103700 regulatory_class = polyA_signal_sequence
  • Loc: 103822-103827 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
envelope glycoprotein C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002229.3 Reference assembly

    Range
    102164..103827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001033973.1 envelope glycoprotein C [Gallid alphaherpesvirus 2]

    See identical proteins and their annotated locations for YP_001033973.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P22651, P33500, Q6LAR3, Q77MR8
    UniProtKB/TrEMBL
    C8JQT0, Q6YL27, Q8JLV7
    Conserved Domains (1) summary
    PHA03271
    Location:1 → 501
    PHA03271; envelope glycoprotein C; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
VGBEMB.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases