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NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 4835, updated on 28-Oct-2024

Summary

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Official Symbol
NQO2provided by HGNC
Official Full Name
N-ribosyldihydronicotinamide:quinone dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:7856
See related
Ensembl:ENSG00000124588 MIM:160998; AllianceGenome:HGNC:7856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QR2; DHQV; DIA6; NMOR2
Summary
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in kidney (RPKM 43.3), fat (RPKM 18.6) and 24 other tissues See more
Orthologs
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Genomic context

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See NQO2 in Genome Data Viewer
Location:
6p25.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (2999894..3019755)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (2868796..2888657)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3000128..3019989)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene serpin family B member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2960063-2960678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2971582-2972106 Neighboring gene SERPINB6-LINC01011 intergenic CAGE-defined mid-level expression enhancer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2988143-2988952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:2988953-2989762 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2989763-2990572 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:2990573-2991380 Neighboring gene long intergenic non-protein coding RNA 1011 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:2994147-2994331 Neighboring gene NQO2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:3014049-3014548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:3017263-3017764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:3017765-3018264 Neighboring gene HIV-1 Tat specific factor 1 pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:3023471-3024670 Neighboring gene uncharacterized LOC101927759 Neighboring gene Sharpr-MPRA regulatory region 12329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23882 Neighboring gene family with sequence similarity 136 member B, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Morphological features, distribution and compartmental organization of the nicotinamide adenine dinucleotide phosphate reduced-diaphorase interneurons in the human striatum. Bernácer J, et al. J Comp Neurol, 2005 Aug 29. PMID 16025450
  2. Increased hippocampal quinone reductase 2 in Alzheimer's disease. Hashimoto T, et al. Neurosci Lett, 2011 Sep 8. PMID 21803122
  3. Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future. Janda E, et al. Genes (Basel), 2024 Jan 10. PMID 38254976, Free PMC Article
  4. Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53. Yu KD, et al. Hum Mol Genet, 2009 Jul 1. PMID 19351655
  5. The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). Winger JA, et al. BMC Struct Biol, 2009 Feb 24. PMID 19236722, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future.
    Title: Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future.
  2. An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.
    Title: An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.
  3. Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.
    Title: Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.
  4. these data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to reactive oxygen species-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals
    Title: Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.
  5. The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2).
    Title: The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2).
  6. In patients with Alzheimer's disease, QR2 is overexpressed in the insular cotex.
    Title: Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.
  7. NQO2-L47 is less stable towards proteolytic digestion and thermal denaturation than NQO2-F47.
    Title: The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.
  8. NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population.
    Title: Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.
  9. This first structure of a reduced quinone reductase shows that reduction of the FAD cofactor and binding of a specific inhibitor lead to global changes in NQO2 structure and is consistent with a functional role for NQO2 as a flavin redox switch.
    Title: Chloroquine binding reveals flavin redox switch function of quinone reductase 2.
  10. Diplotypes of NQO1 (exon 4 and 6), C-T (OR = 1.56, Pc = 0.007) and T-T (OR = 0.011, Pc = 3.86) was associated with an increased risk for prostate cancer (PCa). NQO2 and MTHFR did not show any risk with PCa.
    Title: Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydronicotinamide riboside quinone reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables melatonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables resveratrol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in quinone catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ribosyldihydronicotinamide dehydrogenase [quinone]
Names
N-ribosyldihydronicotinamide:quinone reductase 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2
NAD(P)H quinone dehydrogenase 2
NRH:quinone oxidoreductase 2
quinone reductase 2
ribosyldihydronicotinamide dehydrogenase
NP_000895.2
NP_001277150.1
NP_001277151.1
NP_001305869.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034013.1 RefSeqGene

    Range
    5079..24940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000904.6 → NP_000895.2  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_000895.2

    Status: REVIEWED

    Source sequence(s)
    AL133351
    Consensus CDS
    CCDS4481.1
    UniProtKB/Swiss-Prot
    B2R492, P16083, Q5TD04
    UniProtKB/TrEMBL
    B3KPX6
    Related
    ENSP00000369822.4, ENST00000380455.11
    Conserved Domains (1) summary
    pfam02525
    Location:5 → 212
    Flavodoxin_2; Flavodoxin-like fold

  2. NM_001290221.2 → NP_001277150.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    See identical proteins and their annotated locations for NP_001277150.1

    Status: REVIEWED

    Source sequence(s)
    AL133351
    Consensus CDS
    CCDS4481.1
    UniProtKB/Swiss-Prot
    B2R492, P16083, Q5TD04
    UniProtKB/TrEMBL
    B3KPX6
    Related
    ENSP00000337773.2, ENST00000338130.7
    Conserved Domains (1) summary
    pfam02525
    Location:5 → 212
    Flavodoxin_2; Flavodoxin-like fold

  3. NM_001290222.2 → NP_001277151.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

    See identical proteins and their annotated locations for NP_001277151.1

    Status: REVIEWED

    Source sequence(s)
    AL133351
    Consensus CDS
    CCDS75388.1
    UniProtKB/TrEMBL
    B3KPX6, Q5TD07
    Related
    ENSP00000369821.4, ENST00000380454.8
    Conserved Domains (1) summary
    pfam02525
    Location:5 → 174
    Flavodoxin_2; Flavodoxin-like fold

  4. NM_001318940.2 → NP_001305869.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL133351
    Consensus CDS
    CCDS4481.1
    UniProtKB/Swiss-Prot
    B2R492, P16083, Q5TD04
    UniProtKB/TrEMBL
    B3KPX6
    Related
    ENSP00000369795.1, ENST00000380430.6
    Conserved Domains (1) summary
    pfam02525
    Location:5 → 212
    Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    2999894..3019755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    2868796..2888657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16083.5 GenPept UniProtKB/Swiss-Prot:P16083

Gene LinkOut

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