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NNMT nicotinamide N-methyltransferase [ Homo sapiens (human) ]

Gene ID: 4837, updated on 10-Mar-2024

Summary

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Official Symbol
NNMTprovided by HGNC
Official Full Name
nicotinamide N-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:7861
See related
Ensembl:ENSG00000166741 MIM:600008; AllianceGenome:HGNC:7861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 188.3), appendix (RPKM 69.3) and 10 other tissues See more
Orthologs
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Genomic context

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Location:
11q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114257806..114313536)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114268171..114323905)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114128528..114184258)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113906845-113907785 Neighboring gene Sharpr-MPRA regulatory region 6346 Neighboring gene Sharpr-MPRA regulatory region 5585 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962252-113962768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962769-113963283 Neighboring gene MPRA-validated peak1475 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030299-114030800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030801-114031300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114034953-114035454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114035455-114035954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083238-114083738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083739-114084239 Neighboring gene Sharpr-MPRA regulatory region 4637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114111177-114111676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114128337-114128865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:114166597-114167097 Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:114270475-114271017 and GRCh37_chr11:114271018-114271560 Neighboring gene chromosome 11 open reading frame 71

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids. Zhao H, et al. Oncogene, 2023 Apr. PMID 36823377
  2. NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer. Liu W, et al. Dis Markers, 2023. PMID 36817086, Free PMC Article
  3. Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma. Zhang W, et al. Biomolecules, 2022 Oct 15. PMID 36291696, Free PMC Article
  4. Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer. Ogawa M, et al. Sci Rep, 2022 Feb 17. PMID 35177765, Free PMC Article
  5. Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution. Parsons RB, et al. Biomolecules, 2021 Sep 28. PMID 34680055, Free PMC Article

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
    Title: NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
  2. NNMT enriches for AQP5[+] cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
    Title: NNMT enriches for AQP5(+) cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
  3. Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression.
    Title: Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression.
  4. Nicotinamide N -methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.
    Title: Nicotinamide N -methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.
  5. Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.
    Title: Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.
  6. Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance.
    Title: Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance.
  7. Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.
    Title: Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.
  8. NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer.
    Title: NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer.
  9. Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma.
    Title: Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma.
  10. NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.
    Title: NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.
Submit: New GeneRIF Correction See all GeneRIFs (96)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of nicotinamide N-methyltransferase (NNMT) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nicotinamide N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinamide N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nicotinamide N-methyltransferase activity TAS
Traceable Author Statement
more info
  
enables pyridine N-methyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
  
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation TAS
Traceable Author Statement
more info
  
involved_in nicotinamide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nicotinamide N-methyltransferase
NP_001358974.1
NP_001358975.1
NP_001358976.1
NP_006160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372045.1 → NP_001358974.1  nicotinamide N-methyltransferase

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Consensus CDS
    CCDS8368.1
    UniProtKB/Swiss-Prot
    P40261
    UniProtKB/TrEMBL
    A0A024R3J0, B0YJ53, Q6FH49
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

  2. NM_001372046.1 → NP_001358975.1  nicotinamide N-methyltransferase

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Consensus CDS
    CCDS8368.1
    UniProtKB/Swiss-Prot
    P40261
    UniProtKB/TrEMBL
    A0A024R3J0, B0YJ53, Q6FH49
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

  3. NM_001372047.1 → NP_001358976.1  nicotinamide N-methyltransferase

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Consensus CDS
    CCDS8368.1
    UniProtKB/Swiss-Prot
    P40261
    UniProtKB/TrEMBL
    A0A024R3J0, B0YJ53, Q6FH49
    Related
    ENSP00000441434.1, ENST00000535401.5
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

  4. NM_006169.3 → NP_006160.1  nicotinamide N-methyltransferase

    See identical proteins and their annotated locations for NP_006160.1

    Status: REVIEWED

    Source sequence(s)
    AP002518
    Consensus CDS
    CCDS8368.1
    UniProtKB/Swiss-Prot
    P40261
    UniProtKB/TrEMBL
    A0A024R3J0, B0YJ53, Q6FH49
    Related
    ENSP00000299964.3, ENST00000299964.4
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RNA

  1. NR_164073.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP002518

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    114257806..114313536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    114268171..114323905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40261.1 GenPept UniProtKB/Swiss-Prot:P40261

Gene LinkOut

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