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NPR1 natriuretic peptide receptor 1 [ Homo sapiens (human) ]

Gene ID: 4881, updated on 2-Nov-2024

Summary

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Official Symbol
NPR1provided by HGNC
Official Full Name
natriuretic peptide receptor 1provided by HGNC
Primary source
HGNC:HGNC:7943
See related
Ensembl:ENSG00000169418 MIM:108960; AllianceGenome:HGNC:7943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
Summary
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Expression
Biased expression in fat (RPKM 49.0), lung (RPKM 10.4) and 9 other tissues See more
Orthologs
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Genomic context

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See NPR1 in Genome Data Viewer
Location:
1q21.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153678688..153693992)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152815953..152831256)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153651164..153666468)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SNAP associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1754 Neighboring gene tRNA-iMet (anticodon CAT) 1-1 Neighboring gene interleukin enhancer binding factor 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153650401-153651382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153651383-153652363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153656981-153657482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153657483-153657982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153659386-153660585 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153700292-153700463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153706223-153706722 Neighboring gene integrator complex subunit 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:153717251-153717990 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153717991-153718730 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human plasmacytoid dendritic cells express an atrial natriuretic peptide receptor, guanylyl cyclase-A. Morita R, et al. Microbiol Immunol, 2009 Jul. PMID 19563399
  2. NPR-A: A Therapeutic Target in Inflammation and Cancer. Zhang J, et al. Crit Rev Eukaryot Gene Expr, 2015. PMID 25955817
  3. Atrial natriuretic peptide inhibits cell cycle activity of embryonic cardiac progenitor cells via its NPRA receptor signaling axis. Hotchkiss A, et al. Am J Physiol Cell Physiol, 2015 Apr 1. PMID 25631869
  4. Expression of natriuretic peptide receptor-A in esophageal squamous cell carcinomas and the relationship with tumor invasion and migration. Zhao Z, et al. World J Surg Oncol, 2014 May 21. PMID 24885858, Free PMC Article
  5. Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese. Usami S, et al. Hypertens Res, 2008 Jan. PMID 18360023

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic NPR1 loss of function variants are responsible for neonatal systemic hypertension.
    Title: Biallelic NPR1 loss of function variants are responsible for neonatal systemic hypertension.
  2. Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi.
    Title: Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi.
  3. Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.
    Title: Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.
  4. Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process.
    Title: Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process.
  5. ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP Axis by Interfering with Canonical, Non-Canonical, and Alternative Routes of Inflammasome Activation in Human THP1 Cells.
    Title: ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP Axis by Interfering with Canonical, Non-Canonical, and Alternative Routes of Inflammasome Activation in Human THP1 Cells.
  6. The minor alleles of rs35479618 (p.E967K, gnomAD non-Finnish European allele frequency 0.017) and rs116245325 (p.L1034F, allele frequency 0.0007) of NRP1 were associated with higher blood pressure. [Meta analysis]
    Title: Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity.
  7. Data show that all the residues of the ATP-binding site of the are conserved in the phosphorylated pseudokinase domain (PKD) of atrial natriuretic peptide receptor type A (GC-A) and atrial natriuretic factor receptor B (GC-B).
    Title: The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.
  8. The role of NPR1 signaling in the diabetic complications.[review]
    Title: Molecular and genetic aspects of guanylyl cyclase natriuretic peptide receptor-A in regulation of blood pressure and renal function.
  9. It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots.
    Title: Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro.
  10. These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.
    Title: Enhanced expression of natriuretic peptide receptor A and B in neutrophils of culprit lesions in patients with acute myocardial infarction.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled peptide receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hormone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables natriuretic peptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in blood vessel diameter maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in body fluid secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of renal sodium excretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of urine volume TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of blood pressure NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of vascular permeability TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ANPR-A receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
atrial natriuretic peptide receptor 1
Names
ANP-A
ANPR-A
GC-A
NPR-A
atrial natriuretic peptide receptor type A
atrionatriuretic peptide receptor A
guanylate cyclase A
natriuretic peptide A type receptor
natriuretic peptide receptor A
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
testicular tissue protein Li 20
NP_000897.3
XP_005245275.1
XP_016856863.1
XP_054192771.1
XP_054192772.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000906.4 → NP_000897.3  atrial natriuretic peptide receptor 1 precursor

    See identical proteins and their annotated locations for NP_000897.3

    Status: VALIDATED

    Source sequence(s)
    AK025024
    Consensus CDS
    CCDS1051.1
    UniProtKB/Swiss-Prot
    B0ZBF0, P16066, Q5SR08, Q6P4Q3
    UniProtKB/TrEMBL
    A0A140VJE6
    Related
    ENSP00000357669.3, ENST00000368680.4
    Conserved Domains (7) summary
    cd06385
    Location:36 → 443
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00219
    Location:547 → 801
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:840 → 1032
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:534 → 807
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:867 → 1053
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:54 → 414
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:816 → 861
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153678688..153693992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245218.3 → XP_005245275.1  atrial natriuretic peptide receptor 1 isoform X1

    Conserved Domains (6) summary
    cd06385
    Location:36 → 443
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00044
    Location:814 → 1006
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:534 → 781
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:841 → 1027
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:54 → 414
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:790 → 835
    HNOBA; Heme NO binding associated

  2. XM_017001374.3 → XP_016856863.1  atrial natriuretic peptide receptor 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152815953..152831256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336796.1 → XP_054192771.1  atrial natriuretic peptide receptor 1 isoform X1

  2. XM_054336797.1 → XP_054192772.1  atrial natriuretic peptide receptor 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16066.1 GenPept UniProtKB/Swiss-Prot:P16066

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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