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EID3 EP300 interacting inhibitor of differentiation 3 [ Homo sapiens (human) ]

Gene ID: 493861, updated on 2-Nov-2024

Summary

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Official Symbol
EID3provided by HGNC
Official Full Name
EP300 interacting inhibitor of differentiation 3provided by HGNC
Primary source
HGNC:HGNC:32961
See related
Ensembl:ENSG00000255150 MIM:612986; AllianceGenome:HGNC:32961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS4EB; NSE4B; NSMCE4B
Summary
Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See EID3 in Genome Data Viewer
Location:
12q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104303739..104305205)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104265457..104266923)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104697517..104698983)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23757 Neighboring gene long intergenic non-protein coding RNA 2385 Neighboring gene Sharpr-MPRA regulatory region 15351 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104609333-104609949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104609950-104610565 Neighboring gene NFE2L2 motif-containing MPRA enhancer 194 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23775 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23777 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104628245-104628471 Neighboring gene thioredoxin reductase 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23786 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23788 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23792 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23801 Neighboring gene uncharacterized LOC124903002 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23817 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:104665873-104667072 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23822 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23828 Neighboring gene ribosomal protein L18a pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5029 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:104680011-104681210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104681597-104682144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104682145-104682690 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23836 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104697445-104698317 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23854 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104736854-104737098 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23864 Neighboring gene Sharpr-MPRA regulatory region 7710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104761070-104761775 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104765060-104765816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104765817-104766574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104766575-104767330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104768893-104769404 Neighboring gene uncharacterized LOC105369949 Neighboring gene MPRA-validated peak1927 silencer Neighboring gene uncharacterized LOC124903003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway. Wang Y, et al. Oxid Med Cell Longev, 2022. PMID 36071872, Free PMC Article
  2. Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence. Wang Y, et al. Biomed Pharmacother, 2018 Nov. PMID 30114644
  3. EID3 directly associates with DNMT3A during transdifferentiation of human umbilical cord mesenchymal stem cells to NPC-like cells. Luo L, et al. Sci Rep, 2017 Jan 11. PMID 28074931, Free PMC Article
  4. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Båvner A, et al. Nucleic Acids Res, 2005. PMID 15987788, Free PMC Article
  5. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. Sasajima Y, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15970276

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK.
    Title: EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK.
  2. EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.
    Title: EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.
  3. Knockdown of EID3 by specific shRNA attenuated BMS-345541 -induced radiosensitization in MCF-7 cells.
    Title: Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence.
  4. These findings indicated a novel mechanism by which EID3, a p300 acetyltransferase inhibitor, could directly affect DNMT3A, this enzyme possesses dual methylation and demethylation abilities.
    Title: EID3 directly associates with DNMT3A during transdifferentiation of human umbilical cord mesenchymal stem cells to NPC-like cells.
  5. EID3 acts as an inhibitor of CBP/p300-dependent transcription in a tissue-specific manner.
    Title: EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin looping NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair via homologous recombination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein sumoylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of telomere maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Smc5-Smc6 complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromosome, telomeric region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EP300-interacting inhibitor of differentiation 3
Names
E1A-like inhibitor of differentiation 3
EID-1-like inhibitor of differentiation 3
EID-3
NSE4 homolog B
non-SMC element 4 homolog B
non-structural maintenance of chromosomes element 4 homolog B
testis tissue sperm-binding protein Li 96mP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008394.3 → NP_001008395.1  EP300-interacting inhibitor of differentiation 3

    See identical proteins and their annotated locations for NP_001008395.1

    Status: VALIDATED

    Source sequence(s)
    BC027612, BI461575
    Consensus CDS
    CCDS53822.1
    UniProtKB/Swiss-Prot
    Q8N140
    UniProtKB/TrEMBL
    A0A140VJI9
    Related
    ENSP00000435619.1, ENST00000527879.2
    Conserved Domains (2) summary
    pfam08743
    Location:240 → 328
    Nse4_C; Nse4 C-terminal
    pfam15412
    Location:89 → 137
    Nse4-Nse3_bdg; Binding domain of Nse4/EID3 to Nse3-MAGE

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    104303739..104305205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    104265457..104266923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N140.1 GenPept UniProtKB/Swiss-Prot:Q8N140

Gene LinkOut

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