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PHOSPHO2 phosphatase, orphan 2 [ Homo sapiens (human) ]

Gene ID: 493911, updated on 2-Nov-2024

Summary

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Official Symbol
PHOSPHO2provided by HGNC
Official Full Name
phosphatase, orphan 2provided by HGNC
Primary source
HGNC:HGNC:28316
See related
Ensembl:ENSG00000144362 AllianceGenome:HGNC:28316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphatase activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 6.7), prostate (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

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See PHOSPHO2 in Genome Data Viewer
Location:
2q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169694469..169701708)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170174071..170181317)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170550979..170558218)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase G Neighboring gene MPRA-validated peak3919 silencer Neighboring gene cilia and flagella associated protein 210 Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene uncharacterized LOC124906089 Neighboring gene small nucleolar RNA SNORA51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Roberts SJ, et al. Biochim Biophys Acta, 2005 Aug 31. PMID 16054448
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Readthrough PHOSPHO2-KLHL23

Readthrough gene: PHOSPHO2-KLHL23, Included gene: KLHL23

Homology

Clone Names

  • MGC22679, MGC111048

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphatase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyridoxal phosphate phosphatase PHOSPHO2
NP_001008489.1
NP_001186214.1
NP_001186215.1
NP_001186216.1
NP_001186217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008489.4 → NP_001008489.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001008489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    B2RC30, D3DPC7, Q8TCD6
    Related
    ENSP00000352782.3, ENST00000359744.8
    Conserved Domains (1) summary
    pfam06888
    Location:3 → 239
    Put_Phosphatase; Putative Phosphatase

  2. NM_001199285.2 → NP_001186214.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    AK314915, BC106013
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    B2RC30, D3DPC7, Q8TCD6
    Conserved Domains (1) summary
    pfam06888
    Location:3 → 239
    Put_Phosphatase; Putative Phosphatase

  3. NM_001199286.2 → NP_001186215.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013, BI550291, DA211528
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    B2RC30, D3DPC7, Q8TCD6
    Related
    ENSP00000481046.1, ENST00000616524.4
    Conserved Domains (1) summary
    pfam06888
    Location:3 → 239
    Put_Phosphatase; Putative Phosphatase

  4. NM_001199287.2 → NP_001186216.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013, BM820383, DA211528
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    B2RC30, D3DPC7, Q8TCD6
    Related
    ENSP00000481680.1, ENST00000616481.4
    Conserved Domains (1) summary
    pfam06888
    Location:3 → 239
    Put_Phosphatase; Putative Phosphatase

  5. NM_001199288.2 → NP_001186217.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013, DA211528, DB443540
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    B2RC30, D3DPC7, Q8TCD6
    Related
    ENSP00000481857.1, ENST00000617738.4
    Conserved Domains (1) summary
    pfam06888
    Location:3 → 239
    Put_Phosphatase; Putative Phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    169694469..169701708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    170174071..170181317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCD6.1 GenPept UniProtKB/Swiss-Prot:Q8TCD6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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