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eps8l3.S EPS8-like 3 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495088, updated on 4-Nov-2024

Summary

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Official Symbol
eps8l3.S
Official Full Name
EPS8-like 3 S homeolog
Primary source
Xenbase:XB-GENE-982668
Locus tag
XELAEV_18014919mg
See related
EnsemblRapid:ENSXLAG00005001986 AllianceGenome:Xenbase:XB-GENE-982668
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
eps8l3; lapl03
Summary
Predicted to enable actin binding activity. Predicted to act upstream of or within Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in ruffle membrane and vesicle. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 signaling adaptor L3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eps8l3.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (61155114..61229457, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (57109605..57184579, complement)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 2 S homeolog Neighboring gene glutathione S-transferase Mu 4-like Neighboring gene uncharacterized LOC121400546 Neighboring gene glutathione S-transferase mu 1 S homeolog Neighboring gene piggyBac transposable element-derived protein 4-like Neighboring gene uncharacterized LOC121400346

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An atlas of differential gene expression during early Xenopus embryogenesis. Pollet N, et al. Mech Dev, 2005 Mar. PMID 15763213
  2. Axeldb: a Xenopus laevis database focusing on gene expression. Pollet N, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592204, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EPS8-like 3 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094788.1 → NP_001088257.1  EPS8-like 3 S homeolog

    See identical proteins and their annotated locations for NP_001088257.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084255
    UniProtKB/TrEMBL
    A0A974HVG4, Q5XH20
    Related
    ENSXLAP00005005991.1, ENSXLAT00005006097.1
    Conserved Domains (2) summary
    cd11764
    Location:435 → 488
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 174
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    61155114..61229457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018248397.2 → XP_018103886.1  EPS8-like 3 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UH79, A0A974HVG4
    Related
    ENSXLAP00005005995.1, ENSXLAT00005006101.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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