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K5 K5 [ Human gammaherpesvirus 8 ]

Gene ID: 4961442, updated on 18-Aug-2023

Summary

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Gene symbol
K5
Gene description
K5
Locus tag
HHV8GK18_gp16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (25865..26635, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene K4 Neighboring gene K4.1 Neighboring gene K4.2 Neighboring gene K6 Neighboring gene miscRNA Neighboring gene K7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse components. Adang LA, et al. J Virol, 2007 May. PMID 17329329, Free PMC Article
  2. The Kaposi's sarcoma-associated herpesvirus K5 E3 ubiquitin ligase modulates targets by multiple molecular mechanisms. Means RE, et al. J Virol, 2007 Jun. PMID 17409151, Free PMC Article
  3. The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation. Karki R, et al. PLoS Pathog, 2011 Apr. PMID 21490960, Free PMC Article
  4. Palmitoylation of MIR2 is required for its function. Anania VG, et al. J Virol, 2011 Mar. PMID 21159884, Free PMC Article
  5. Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization. Goto E, et al. J Biol Chem, 2010 Nov 12. PMID 20833710, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kaposi's sarcoma-associated herpesvirus ubiquitin ligases downregulate cell surface expression of l-selectin.
    Title: Kaposi's sarcoma-associated herpesvirus ubiquitin ligases downregulate cell surface expression of l-selectin.
  2. This work ascribes a critical function to PLP2 for viral ligase activity and underlines the power of non-lethal haploid genetic screens in human cells to identify the genes involved in pathogen manipulation of the host immune system.
    Title: Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.
  3. Both K3 and K5 preferentially associate with DC-SIGN and DC-SIGNR, mediating their ubiquitylation and degradation.
    Title: Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR.
  4. Phe119 and Ser120 in the MIR2 ITM region and Asp244 in the B7-2 JM region contribute to the recognition of B7-2 by MIR2.
    Title: The intertransmembrane region of Kaposi's sarcoma-associated herpesvirus modulator of immune recognition 2 contributes to B7-2 downregulation.
  5. We provide evidence that the KSHV K5 protein is able to drive alterations in cellular signaling cascades, potentially contributing to KSHV oncogenesis.
    Title: The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation.
  6. Palmitoylation act to regulate MIR2 function and localization during viral infection.
    Title: Palmitoylation of MIR2 is required for its function.
  7. Data show that the polyubiquitin chain generated by the viral E3 ubiquitin ligase, MIR2, is a Lys(11) and Lys(63) mixed-linkage chain, and this ubiquitin chain can function as an internalization signal for MHC I.
    Title: Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization.
  8. K5-mediated inhibition of the capture of effector memory CD4-positive T cells can be explained by ubiquitin-dependent downregulation of ICAM-1 expression.
    Title: Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins block distinct steps in transendothelial migration of effector memory CD4+ T cells by targeting different endothelial proteins.
  9. K5 is a mechanistically distinct viral countermeasure to tetherin-mediated restriction
    Title: The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin.
  10. KSHV release is decreased in the absence of K5 in a BST2-dependent manner, suggesting that K5 contributes to the evasion of intracellular antiviral defense programs
    Title: Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
K5
Names
MIR2
YP_001129365.1
  • membrane protein; related to K3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    25865..26635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129365.1 K5 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129365.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D0UZM4, P90489, Q2HRC0
    UniProtKB/TrEMBL
    A0A0N9SF34, A0A0N9SM15, F5H9K4
    Conserved Domains (1) summary
    smart00744
    Location:14 → 60
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
Nucleotide Protein
Heading Accession and Version

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