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vIRF-1 K9 [ Human gammaherpesvirus 8 ]

Gene ID: 4961464, updated on 5-May-2024

Summary

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Gene symbol
vIRF-1
Gene description
K9
Locus tag
HHV8GK18_gp62
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (83887..85415, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF55 Neighboring gene ORF56 Neighboring gene ORF57 Neighboring gene vIRF-4 Neighboring gene vIRF-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry. Choi YB, et al. PLoS Pathog, 2012. PMID 22685405, Free PMC Article
  2. The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor. Hew K, et al. Nucleic Acids Res, 2013 Apr. PMID 23435230, Free PMC Article
  3. Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway. Li W, et al. PLoS Pathog, 2020 Aug. PMID 32776977, Free PMC Article
  4. Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. Chavoshi S, et al. J Biol Chem, 2016 Mar 18. PMID 26786098, Free PMC Article
  5. Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. Hwang KY, et al. J Virol, 2016 Jan 1. PMID 26512076, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
    Title: Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
  2. Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway.
    Title: Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway.
  3. ubiquitin-specific protease 7 (USP7) deubiquitinase targeting by vIRF-3 (in addition to previously reported USP7 binding by vIRF-1 and vIRF-4); the importance of vIRF-1 and vIRF-3 interactions with USP7 for latent PEL cell growth and viability; and the positive and negative contributions, respectively, of USP7 targeting by vIRF-1 and vIRF-3 to HHV-8 productive replication.
    Title: Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase.
  4. These results suggest that vIRF-1 is the first example of a viral protein to inhibit mitochondrial antiviral signaling through lipid raft-like microdomains.
    Title: Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1.
  5. vIRF1 association with HERC5 altered ISG15 modification of cellular proteins, and knockdown of ISG15 augmented reactivation of KSHV from latency.
    Title: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway.
  6. The complex structure of vIRF-1 DNA-binding domain reveals interactions with the DNA backbone and the positioning of two arginines for specific recognition in the major grove.
    Title: The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor.
  7. Kaposi's sarcoma-associated herpesvirus vIRF1 and vIRF2 inhibited increases in both IFN-beta message and protein levels following TLR3 activation.
    Title: The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.
  8. data demonstrate and characterize BH3 targeting and associated inhibition of BH3-only protein pro-apoptotic activity by vIRF-1 via Bid BH3-B mimicry, identifying a novel mechanism of viral evasion from host cell defenses
    Title: Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

polyA_site

  • Loc: c83887

regulatory

  • Loc: c83908-83903 regulatory_class = polyA_signal_sequence
  • Loc: c85415-85410 regulatory_class = TATA_box

General protein information

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Preferred Names
K9
Names
vIRF-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    83887..85415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129411.1 vIRF-1 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129411.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HF68
    UniProtKB/TrEMBL
    A0A0N9RX90, A0A0N9SEG2, A0A0N9SGV7, A0A7D5FWC9, P88946, Q2HR74, Q77Q82
    Conserved Domains (2) summary
    smart00348
    Location:91 → 196
    IRF; interferon regulatory factor
    pfam10401
    Location:257 → 386
    IRF-3; Interferon-regulatory factor 3
Nucleotide Protein
Heading Accession and Version

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