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ORF45 ORF45 [ Human gammaherpesvirus 8 ]

Gene ID: 4961474, updated on 18-Aug-2023

Summary

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Gene symbol
ORF45
Gene description
ORF45
Locus tag
HHV8GK18_gp51
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (67444..68675, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF40 Neighboring gene ORF42 Neighboring gene ORF43 Neighboring gene ORF44 Neighboring gene ORF46 Neighboring gene ORF47 Neighboring gene ORF48 Neighboring gene ORF50 Neighboring gene ORF49 Neighboring gene K8 Neighboring gene K8.1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication. Kuang E, et al. J Virol, 2008 Feb. PMID 18057234, Free PMC Article
  2. Identification of the nuclear export and adjacent nuclear localization signals for ORF45 of Kaposi's sarcoma-associated herpesvirus. Li X, et al. J Virol, 2009 Mar. PMID 19116250, Free PMC Article
  3. Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication. Avey D, et al. PLoS Pathog, 2015 Jul. PMID 26133373, Free PMC Article
  4. Host RAB11FIP5 protein inhibits the release of Kaposi's sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45. Wei X, et al. PLoS Pathog, 2020 Dec. PMID 33315947, Free PMC Article
  5. Discovery of a Coregulatory Interaction between Kaposi's Sarcoma-Associated Herpesvirus ORF45 and the Viral Protein Kinase ORF36. Avey D, et al. J Virol, 2016 Jul 1. PMID 27099309, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.
    Title: Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.
  2. A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
    Title: A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
  3. Host RAB11FIP5 protein inhibits the release of Kaposi's sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45.
    Title: Host RAB11FIP5 protein inhibits the release of Kaposi's sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45.
  4. discovered and characterized a functionally important interaction between KSHV ORF36 and ORF45; results suggest a significant role of ORF36 in the production of infectious progeny virions, a process critical for KSHV pathogenesis
    Title: Discovery of a Coregulatory Interaction between Kaposi's Sarcoma-Associated Herpesvirus ORF45 and the Viral Protein Kinase ORF36.
  5. these data shed light on the mechanisms by which KSHV ORF45 manipulates components of the host cell machinery via modulation of RSK activity.
    Title: Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication.
  6. ORF45 expression was not only upregulated by RTA, but ORF45 could also be degraded by RTA in a proteasome-dependent manner.
    Title: Activation and degradation of open reading frame 45 by the replication and transcription activator of Kaposi's sarcoma-associated herpesvirus.
  7. c-Fos promotes the progression of viral transcription from early to late stages and accelerates viral lytic replication upon sustained ORF45-ERK-RSK activation during the Kaposi's Sarcoma-Associated Herpesvirus lytic life cycle.
    Title: ORF45-Mediated Prolonged c-Fos Accumulation Accelerates Viral Transcription during the Late Stage of Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.
  8. Authors mapped the humna herpesvirus 8 ORF33-binding domain to the highly conserved carboxyl-terminal 19 amino acids (aa) of ORF45 and the human USP7-binding domain to the reported consensus motif in the central region of ORF45.
    Title: A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.
  9. These results suggest a critical role for ORF45-mediated p90 Ribosomal S6 Kinase activation in Kaposi's sarcoma-associated herpesvirus lytic replication.
    Title: Activation of p90 ribosomal S6 kinases by ORF45 of Kaposi's sarcoma-associated herpesvirus is critical for optimal production of infectious viruses.
  10. Kaposi's sarcoma-associated herpesvirus ORF45 mediates activation of the HIV-1 long terminal repeat via RSK2.
    Title: Kaposi's sarcoma-associated herpesvirus ORF45 mediates transcriptional activation of the HIV-1 long terminal repeat via RSK2.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF45

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    67444..68675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129397.1 ORF45 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129397.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HDE4
    UniProtKB/TrEMBL
    A0A0N9RV72, A0A2Z5TRP9, P88933, Q2HR88, Q77UV9
Nucleotide Protein
Heading Accession and Version

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