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vIRF-3 vIRF-3 [ Human gammaherpesvirus 8 ]

Gene ID: 4961493, updated on 18-Aug-2023

Summary

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Gene symbol
vIRF-3
Gene description
vIRF-3
Locus tag
HHV8GK18_gp64
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (89473..91512, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene K9 Neighboring gene vIRF-4 Neighboring gene vIRF-2 Neighboring gene ORF58 Neighboring gene ORF60 Neighboring gene ORF61 Neighboring gene ORF59 Neighboring gene ORF62

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. vIRF3 encoded by Kaposi's sarcoma-associated herpesvirus inhibits T-cell factor-dependent transcription via a CREB-binding protein-interaction motif. Cha S, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27693583
  2. Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and -independent mechanisms: implications for oncogenesis. Zuo J, et al. J Virol, 2013 May. PMID 23449805, Free PMC Article
  3. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expression. Schmidt K, et al. J Virol, 2011 May. PMID 21345951, Free PMC Article
  4. The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells. Wies E, et al. Blood, 2008 Jan 1. PMID 17890449
  5. Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. Lee HR, et al. mBio, 2018 Jan 16. PMID 29339432, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, these data indicate that vIRF3 alters global gene expression and induces a hypersprouting formation in an HDAC5-binding-dependent and lymphatic endothelial cell-specific manner, ultimately contributing to Kaposi's sarcoma-associated herpesvirus-associated pathogenesis.
    Title: Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis.
  2. ubiquitin-specific protease 7 (USP7) deubiquitinase targeting by vIRF-3 (in addition to previously reported USP7 binding by vIRF-1 and vIRF-4); the importance of vIRF-1 and vIRF-3 interactions with USP7 for latent PEL cell growth and viability; and the positive and negative contributions, respectively, of USP7 targeting by vIRF-1 and vIRF-3 to HHV-8 productive replication.
    Title: Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase.
  3. this study identified a CREB-binding protein-interaction motif (LXXLL) in vIRF3 as an important region for its activity to inhibit T-cell factor-dependent transcription.
    Title: vIRF3 encoded by Kaposi's sarcoma-associated herpesvirus inhibits T-cell factor-dependent transcription via a CREB-binding protein-interaction motif.
  4. Data show that human herpesvirus 8 viral interferon regulatory factor 3 (vIRF-3) associates with the DNA-binding domain of p53, inhibits p53 phosphorylation on serine residues S15 and S20, and antagonizes p53 oligomerization and the DNA-binding affinity.
    Title: p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3.
  5. Here the authors report that the virus-encoded interferon regulatory factor 3 (vIRF3) latent viral gene expressed in Kaposi's sarcoma-associated herpesvirus-related tumors functions as a potent immunevasin.
    Title: Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and -independent mechanisms: implications for oncogenesis.
  6. The authors conclude that vIRF-3 contributes to the viral immunoevasion by downregulation of IFN-gamma and CIITA and thus MHC II expression.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expression.
  7. vIRF-3 can be seen as a bona fide oncogene of KSHV-associated lymphoma
    Title: The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells.
  8. These findings indicate that vIRF-3 can effectively stimulate c-Myc function in primary effusion lymphoma cells and consequently contribute to de-regulation of B-cell growth and differentiation.
    Title: Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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polyA_site

  • Loc: c89473

regulatory

  • Loc: c89492-89487 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
vIRF-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    89473..91512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129413.1 vIRF-3 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129413.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HIC6
    UniProtKB/TrEMBL
    A0A7D5UH90, Q2HR72, Q99AM3, Q9DUN1
Nucleotide Protein
Heading Accession and Version

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