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vIRF-4 vIRF-4 [ Human gammaherpesvirus 8 ]

Gene ID: 4961495, updated on 14-Jun-2024

Summary

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Gene symbol
vIRF-4
Gene description
vIRF-4
Locus tag
HHV8GK18_gp63
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (86106..89172, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF56 Neighboring gene ORF57 Neighboring gene K9 Neighboring gene vIRF-3 Neighboring gene vIRF-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication. Lee HR, et al. J Virol, 2014 Feb. PMID 24335298, Free PMC Article
  2. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling. Heinzelmann K, et al. J Virol, 2010 Dec. PMID 20861242, Free PMC Article
  3. Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7. Yang Z, et al. J Virol, 2024 Jun 13. PMID 38752725,
  4. Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters. Xi X, et al. J Virol, 2012 Jan. PMID 22090118, Free PMC Article
  5. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. Lee HR, et al. J Virol, 2009 Jul. PMID 19369353, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7.
    Title: Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7.
  2. KSHV-encoded viral IRF4 interacts with the host IRF7 and inhibits interferon-alpha production.
    Title: KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production.
  3. Kaposi's sarcoma-associated herpesvirus vIRF4 targets the beta-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing virus replication.
    Title: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene.
  4. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.
  5. vIRF4 and RTA cooperate to activate the vIRF4 promoter.
    Title: Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters.
  6. Our data suggest that vIRF4 is a potential antagonist of Notch/CBF1 signal transduction.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.
  7. vIRF4 expression reduces MDM2 ubiquitination, enhances p53 ubiquitination and, downregulates p53-mediated apoptosis.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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polyA_site

  • Loc: c86106

regulatory

  • Loc: c86130-86125 regulatory_class = polyA_signal_sequence
  • Loc: c89071-89066 regulatory_class = TATA_box
  • Loc: c89172-89167 regulatory_class = TATA_box

General protein information

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Preferred Names
vIRF-4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    86106..89172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129412.1 vIRF-4 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129412.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D0UZS2, Q2HR73
    UniProtKB/TrEMBL
    A0A0N9SCI5, A0A7D5JR94, A0A7D5KG32, F5H9D8
    Conserved Domains (1) summary
    PHA03247
    Location:232 → 634
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
Heading Accession and Version

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