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ORF34 ORF34;ORF36 [ Human gammaherpesvirus 8 ]

Gene ID: 4961504, updated on 18-Aug-2023

Summary

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Gene symbol
ORF34
Gene description
ORF34;ORF36
Locus tag
HHV8GK18_gp38
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (54635..58974)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF28 Neighboring gene ORF29 Neighboring gene ORF30 Neighboring gene ORF31 Neighboring gene ORF32 Neighboring gene ORF33 Neighboring gene ORF35;ORF37 Neighboring gene Neighboring gene Neighboring gene ORF38 Neighboring gene ORF39 Neighboring gene ORF40 Neighboring gene ORF42 Neighboring gene ORF43

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kaposi's Sarcoma-Associated Herpesvirus ORF66 Is Essential for Late Gene Expression and Virus Production via Interaction with ORF34. Watanabe T, et al. J Virol, 2020 Jan 6. PMID 31694948, Free PMC Article
  2. Conserved Cx(n)C Motifs in Kaposi's Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34. Didychuk AL, et al. J Virol, 2020 Jan 6. PMID 31578296, Free PMC Article
  3. Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production. Nishimura M, et al. Sci Rep, 2017 Mar 23. PMID 28336944, Free PMC Article
  4. Interaction between ORF24 and ORF34 in the Kaposi's Sarcoma-Associated Herpesvirus Late Gene Transcription Factor Complex Is Essential for Viral Late Gene Expression. Davis ZH, et al. J Virol, 2016 Jan 1. PMID 26468530, Free PMC Article
  5. The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains. Haque M, et al. J Virol, 2019 Sep 1. PMID 31189709, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved CxnC Motifs in Kaposi's Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34.
    Title: Conserved Cx(n)C Motifs in Kaposi's Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34.
  2. Kaposi's Sarcoma-Associated Herpesvirus ORF66 Is Essential for Late Gene Expression and Virus Production via Interaction with ORF34.
    Title: Kaposi's Sarcoma-Associated Herpesvirus ORF66 Is Essential for Late Gene Expression and Virus Production via Interaction with ORF34.
  3. Results show that KSHV ORF34 binds and stabilizes HIF-2A, preserving HIF-2A-dependent cellular transcription. In contrast, ORF34 binds HIF-1A and causes its proteasome-dependent degradation. This differential action of ORF34 suggests that it plays a critical role in regulating HIF-1A- and HIF-2A-dependent cellular processes required for successful KSHV infection and tumorigenesis.
    Title: The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains.
  4. These data support a model, in which ORF34 serves as a hub for recruiting a viral transcription complex to ORF24 to promote late viral gene expression.
    Title: Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production.
  5. Disruption of this complex via point mutation of the interaction interface between the open reading frame 24 (ORF24) and ORF34 viral transactivation factors ablated both late gene expression and viral replication.
    Title: Interaction between ORF24 and ORF34 in the Kaposi's Sarcoma-Associated Herpesvirus Late Gene Transcription Factor Complex Is Essential for Viral Late Gene Expression.
  6. A complex consisting of ORF24, ORF31, and ORF34 specifically binds to the K8.1 late promoter and is critical for late gene expression.
    Title: Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression.
  7. These results show that Kaposi's sarcoma-associated herpesvirus ORF34 binds to HIF-1alpha, leading to its degradation via the proteasome-dependent pathway.
    Title: The Kaposi's sarcoma-associated herpesvirus ORF34 protein binds to HIF-1α and causes its degradation via the proteasome pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

polyA_site

  • Loc: 58974

regulatory

  • Loc: 54635-54640 regulatory_class = TATA_box
  • Loc: 55635-55640 regulatory_class = TATA_box
  • Loc: 58952-58957 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
ORF34;ORF36
YP_001129387.1
  • related to HHV-5 UL95
YP_001129389.1
  • herpesvirus core gene UL13 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    54635..58974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129389.1 ORF36 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129389.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HGH5
    UniProtKB/TrEMBL
    A0A0N9S413, P88924, Q2HR96, Q76RH4
    Conserved Domains (1) summary
    cl21453
    Location:88 → 243
    PKc_like; Protein Kinases, catalytic domain

  2. YP_001129387.1 ORF34 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129387.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q2HR98
    UniProtKB/TrEMBL
    Q76SB1, Q98131
    Conserved Domains (1) summary
    pfam03038
    Location:1 → 323
    Herpes_UL95; UL95 family
Nucleotide Protein
Heading Accession and Version

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