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ORF35 ORF35;ORF37 [ Human gammaherpesvirus 8 ]

Gene ID: 4961512, updated on 20-Nov-2023

Summary

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Gene symbol
ORF35
Gene description
ORF35;ORF37
Locus tag
HHV8GK18_gp39
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (55635..58974)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF28 Neighboring gene ORF29 Neighboring gene ORF30 Neighboring gene ORF31 Neighboring gene ORF32 Neighboring gene ORF33 Neighboring gene ORF34;ORF36 Neighboring gene Neighboring gene Neighboring gene ORF38 Neighboring gene ORF39 Neighboring gene ORF40 Neighboring gene ORF42 Neighboring gene ORF43

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production. Hartenian E, et al. Nucleic Acids Res, 2023 Jan 11. PMID 36537232, Free PMC Article
  2. The DNase Activity of Kaposi's Sarcoma-Associated Herpesvirus SOX Protein Serves an Important Role in Viral Genome Processing during Lytic Replication. Uppal T, et al. J Virol, 2019 Apr 15. PMID 30728255, Free PMC Article
  3. Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff. Bagnéris C, et al. Nucleic Acids Res, 2011 Jul. PMID 21421561, Free PMC Article
  4. Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus. Dahlroth SL, et al. FEBS J, 2009 Nov. PMID 19843164
  5. An RNA element in human interleukin 6 confers escape from degradation by the gammaherpesvirus SOX protein. Hutin S, et al. J Virol, 2013 Apr. PMID 23408619, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production.
    Title: DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production.
  2. these results indicated that ORF37's proposed DNase activity is essential for viral genome processing and encapsidation and, hence, can be targeted for designing antiviral agents to block KSHV virion production.
    Title: The DNase Activity of Kaposi's Sarcoma-Associated Herpesvirus SOX Protein Serves an Important Role in Viral Genome Processing during Lytic Replication.
  3. Interaction of IL-6 mRNA with the AU-rich element (ARE) binding proteins AUF1 and HuR prevents its degradation by SOX of human herpesvirus 8.
    Title: An RNA element in human interleukin 6 confers escape from degradation by the gammaherpesvirus SOX protein.
  4. The first crystal structure of a KSHV SOX-DNA complex that has illuminated the catalytic mechanism underpinning both its endo and exonuclease activities.
    Title: Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  5. the crystal structure of SOX determined at 1.85 A resolution
    Title: Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

polyA_site

  • Loc: 58974

regulatory

  • Loc: 55635-55640 regulatory_class = TATA_box
  • Loc: 58952-58957 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
ORF35;ORF37
Names
SOX
YP_001129388.1
  • herpesvirus core gene UL14 family
YP_001129390.1
  • herpesvirus core gene UL12 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    55635..58974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129390.1 ORF37 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129390.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q2HR95
    UniProtKB/TrEMBL
    D0UZP9, P88925
    Conserved Domains (1) summary
    pfam01771
    Location:27 → 478
    Herpes_alk_exo; Herpesvirus alkaline exonuclease

  2. YP_001129388.1 ORF35 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129388.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HCD4
    UniProtKB/TrEMBL
    A0A0N7GEM1, A0A7D5YEY0, P88923, Q2HR97, Q76RH5
    Conserved Domains (1) summary
    pfam05852
    Location:4 → 147
    DUF848; Gammaherpesvirus protein of unknown function (DUF848)
Nucleotide Protein
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