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K4 K4 [ Human gammaherpesvirus 8 ]

Gene ID: 4961514, updated on 21-Jun-2023

Summary

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Gene symbol
K4
Gene description
K4
Locus tag
HHV8GK18_gp13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (21275..21764, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene K3 Neighboring gene ORF70 Neighboring gene K4.1 Neighboring gene K4.2 Neighboring gene K5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the interactions of vMIP-II, and a dimeric variant of vMIP-II, with glycosaminoglycans. Zhao B, et al. Biochemistry, 2010 Aug 24. PMID 20712376, Free PMC Article
  2. Crystal structure of chemically synthesized vMIP-II. Li Y, et al. Proteins, 2007 Apr 1. PMID 17243149
  3. The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1. Wu H, et al. Biosci Rep, 2018 Oct 31. PMID 30104400, Free PMC Article
  4. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Qin L, et al. Science, 2015 Mar 6. PMID 25612609, Free PMC Article
  5. Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. Lüttichau HR, et al. J Biol Chem, 2007 Jun 15. PMID 17403668

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast cancer cells and whether N-terminal polypeptide derived from viral macrophage inflammatory protein II (NT21MP) could exert its anti-tumor effect by regulating lncRNA SPRY4-IT1 and its target gene SKA2
    Title: The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1.
  2. this study reports the crystal structure of the chemokine receptor CXCR4 in complex with the viral chemokine antagonist vMIP-II at 3.1 angstrom resolution.
    Title: Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.
  3. A dimeric vMIP-II mutant binds to heparin much more tightly than wild-type vMIP-II.
    Title: Characterization of the interactions of vMIP-II, and a dimeric variant of vMIP-II, with glycosaminoglycans.
  4. vCCL2 was found to act as a broad spectrum chemokine antagonist of human chemokine receptors, including the lymphotactin receptor
    Title: Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3.
  5. vMIP-II forms crystallographic dimers in our tetragonal crystal through interactions between N-termini, which is the interaction pattern also observed in the asymmetric unit of previously reported crystal form.
    Title: Crystal structure of chemically synthesized vMIP-II.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: c21280-21275 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
K4
Names
vCCL-2
vMIP-II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    21275..21764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129362.1 K4 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129362.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D0UZM1, Q2HRC3, Q98157
    UniProtKB/TrEMBL
    F5HFL9
    Conserved Domains (1) summary
    smart00199
    Location:31 → 89
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
Nucleotide Protein
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