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ORF50 ORF50 [ Human gammaherpesvirus 8 ]

Gene ID: 4961526, updated on 4-Jan-2024

Summary

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Gene symbol
ORF50
Gene description
ORF50
Locus tag
HHV8GK18_gp52
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (71695..76818)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF43 Neighboring gene ORF44 Neighboring gene ORF45 Neighboring gene ORF46 Neighboring gene ORF47 Neighboring gene ORF48 Neighboring gene ORF49 Neighboring gene K8 Neighboring gene K8.1 Neighboring gene ORF52 Neighboring gene ORF53

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein. Calhoun JC, et al. J Virol, 2023 Oct 31. PMID 37750723, Free PMC Article
  2. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Sun R, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724796, Free PMC Article
  3. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer. Bu W, et al. J Virol, 2007 Jun. PMID 17392367, Free PMC Article
  4. A mobile functional region of Kaposi's sarcoma-associated herpesvirus ORF50 protein independently regulates DNA binding and protein abundance. Chang PJ, et al. J Virol, 2008 Oct. PMID 18653447, Free PMC Article
  5. Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression. Bottero V, et al. Virology, 2009 Sep 15. PMID 19640558, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein.
    Title: Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein.
  2. KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivation.
    Title: KSHV RTA utilizes the host E3 ubiquitin ligase complex RNF20/40 to drive lytic reactivation.
  3. KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle.
    Title: KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle.
  4. Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter.
    Title: Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter.
  5. Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters.
    Title: Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters.
  6. Taken together, these results provide a new understanding of the antiviral mechanism of human GBP1, which possesses potent anti-Kaposi's sarcoma-associated herpesvirus activity, and suggest the critical role of viral RTA in the evasion of the innate immune response during primary infection by Kaposi's sarcoma-associated herpesvirus.
    Title: Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament.
  7. The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA induced degradation of vFLIP.
    Title: The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation.
  8. The results show the global viral transactivation potential of all four ORF50 isoforms and demonstrate that all isoforms can transcriptionally activate an array of Kaposi's sarcoma-associated herpesvirus promoters to various levels.
    Title: Identification of Novel Kaposi's Sarcoma-Associated Herpesvirus Orf50 Transcripts: Discovery of New RTA Isoforms with Variable Transactivation Potential.
  9. the study elucidates the regulatory mechanism of ORF50 stability and implicates that MDM2 may have a significant role in the maintenance of viral latency by lowering basal level of ORF50.
    Title: Regulation of the Abundance of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2.
  10. Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins.
    Title: Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 76813-76818 regulatory_class = polyA_signal_sequence

variation

  • Loc: 76723-76796 replace =

General protein information

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Preferred Names
ORF50
Names
RTA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    71695..76818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129401.1 ORF50 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129401.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HCV3
    UniProtKB/TrEMBL
    A0A7D5FWR4, E5LBX1, O92608, Q2HR84
    Conserved Domains (1) summary
    pfam03326
    Location:85 → 651
    Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
Nucleotide Protein
Heading Accession and Version

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