HHV8GK18_gp81 ORF73 [Human gammaherpesvirus 8] - Gene

Summary

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Gene symbol: HHV8GK18_gp81
Gene description: ORF73
Locus tag: HHV8GK18_gp81
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:: NC_009333.1 (123010..127446, complement)

NC_009333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009333.1

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MLL1 is regulated by KSHV LANA and is important for virus latency.
Title: MLL1 is regulated by KSHV LANA and is important for virus latency.
The ORF45 Protein of Kaposi Sarcoma-Associated Herpesvirus Is an Inhibitor of p53 Signaling during Viral Reactivation.
Title: The ORF45 Protein of Kaposi Sarcoma-Associated Herpesvirus Is an Inhibitor of p53 Signaling during Viral Reactivation.
LANA upregulates let-7a and its primary transcripts in parallel with its reduction of RBPJ expression.
Title: Latency-associated nuclear antigen inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by regulating let-7a/RBPJ signaling.
research shows that intact LANA traffics to the cytoplasm of cells undergoing permissive lytic infections and latently infected cells in which the virus is induced to replicate. This suggests that LANA plays important roles in the cytoplasm and nuclear compartments of the cell during different stages of the life Kaposi's sarcoma-associated herpesvirus cycle.
Title: Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication.
The findings highlight a second point at which cytoplasmic LANA interferes with the innate immune response, as well as the importance of the recently discovered role of cytoplasmic MRN complex members as innate sensors of cytoplasmic DNA for the control of KSHV replication.
Title: Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency.
the Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) is capable of supporting Murine Gammaherpesvirus 68 latency in a mouse model of chronic infection but also functions to repress viral replication.
Title: Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs.
KSHV LANA recruits host PRCs onto the lytic promoters to suppress lytic gene expression following de novo infection.
Title: LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection.
Chimeric proteins constructed by fusion of LANA of Kaposi's sarcoma-associated herpesvirus with the NuMA could bind with ori-P and enhance replication of an ori-P-containing plasmid.
Title: A chimeric protein composed of NuMA fused to the DNA binding domain of LANA is sufficient for the ori-P-dependent DNA replication.
This observation points to a novel function of the cytoplasmic isoforms of LANA during lytic replication and extends the function of LANA from its role during latency to the lytic replication cycle.
Title: Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS.
The study shows that KSHV LANA and MHV-68 LANA proteins bind terminal repeat viral DNA using strikingly different modes.
Title: KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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regulatory

Loc: c123015-123010 regulatory_class = polyA_signal_sequence

Repeated regions

Loc: c126456-124784 rpt_family = DR7 , rpt_type = direct

General protein information

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Preferred Names: LANA

Names: LNA; ORF73

YP_001129431.1

component of latency-associated nuclear antigen; LANA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_009333.1 Reference assembly

Range

123010..127446 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_001129431.1 ORF73 [Human gammaherpesvirus 8]

See identical proteins and their annotated locations for YP_001129431.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9QR71

UniProtKB/TrEMBL

A0A7D3QN79

Conserved Domains (1) summary

PHA03169
Location:933 → 1112

PHA03169; hypothetical protein; Provisional