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Cps1 carbamoyl-phosphate synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497840, updated on 28-Oct-2024

Summary

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Official Symbol
Cps1provided by RGD
Official Full Name
carbamoyl-phosphate synthase 1provided by RGD
Primary source
RGD:2395
See related
EnsemblRapid:ENSRNOG00000013704 AllianceGenome:RGD:2395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
cps; cps-1
Summary
Enables several functions, including anion binding activity; calcium ion binding activity; and carbamoyl-phosphate synthase (ammonia) activity. Involved in several processes, including cellular response to cAMP; cellular response to glucagon stimulus; and cellular response to oleic acid. Located in mitochondrial inner membrane. Part of protein-containing complex. Biomarker of hypertension; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 9686.1) See more
Orthologs
human mouse all
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Genomic context

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See Cps1 in Genome Data Viewer
Location:
9q32
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (76063863..76186739)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (68614153..68737037)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (74113437..74236274)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL32-like Neighboring gene uncharacterized LOC134480382 Neighboring gene LanC like glutathione S-transferase 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480291

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Arginine synthesis by hepatomas in vitro. II. Isolation and characterization of Morris hepatoma variants unable to convert ornithine to arginine, and modulation of urea-cycle enzymes by dexamethasone and cyclic-AMP. Goss SJ. J Cell Sci, 1984 Jun. PMID 6092398
  2. Calcium binding to polypeptides of rat liver and Zajdela hepatoma mitochondrial inner membranes. Evtodienko YV, et al. FEBS Lett, 1998 Feb 13. PMID 9506839
  3. Expression of messenger RNA for liver functions following 70% and 90% hepatectomy. Tygstrup N, et al. J Hepatol, 1996 Jul. PMID 8836904
  4. Required allosteric effector site for N-acetylglutamate on carbamoyl-phosphate synthetase I. McCudden CR, et al. J Biol Chem, 1996 Jul 26. PMID 8663466
  5. Regulation of mitochondrial carbamoyl-phosphate synthetase 1 activity by active site fatty acylation. Corvi MM, et al. J Biol Chem, 2001 Dec 7. PMID 11577071

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury.
    Title: Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.
  2. The relationship between carbamoylphosphate synthetase-I expression and in vivo occupancy of the response elements was examined.
    Title: Hepatocyte-specific interplay of transcription factors at the far-upstream enhancer of the carbamoylphosphate synthetase gene upon glucocorticoid induction.
  3. cyclicAMP and glucocorticoid pathways can induce CPS transcription via overlapping sets of response elements
    Title: cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstream regulatory units.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables carbamoyl-phosphate synthase (ammonia) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbamoyl-phosphate synthase (ammonia) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbamoyl-phosphate synthase (ammonia) activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
enables modified amino acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables potassium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbamoyl phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ammonium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to fibroblast growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to glucagon stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to oleic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hepatocyte differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in midgut development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in monoatomic anion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitric oxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to food IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucagon IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to growth hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oleic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urea cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carbamoyl-phosphate synthase [ammonia], mitochondrial
Names
CPSase I
carbamoyl-phosphate synthetase 1, mitochondrial
carbamoyl-phosphate synthetase I
carbamyl phosphate synthetase I
carbamyl-phosphate synthetase
carboamyl-phosphate synthetase 1
NP_058768.1
XP_017452081.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017072.2 → NP_058768.1  carbamoyl-phosphate synthase [ammonia], mitochondrial precursor

    See identical proteins and their annotated locations for NP_058768.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P07756
    UniProtKB/TrEMBL
    A6KFE3, A6KFE6
    Conserved Domains (8) summary
    cd01744
    Location:220 → 395
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    smart01096
    Location:839 → 962
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
    cd01423
    Location:1360 → 1475
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01368
    Location:46 → 400
    CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
    TIGR01369
    Location:419 → 1477
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00988
    Location:46 → 183
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02786
    Location:546 → 748
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    cl17255
    Location:1088 → 1289
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    76063863..76186739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596592.3 → XP_017452081.1  carbamoyl-phosphate synthase [ammonia], mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P07756
    UniProtKB/TrEMBL
    A6KFE3, A6KFE6
    Related
    ENSRNOP00000019021.5, ENSRNOT00000019023.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07756.1 GenPept UniProtKB/Swiss-Prot:P07756

Gene LinkOut

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