C1qtnf2 C1q and TNF related 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qtnf2provided by RGD
Official Full Name: C1q and TNF related 2provided by RGD
Primary source: RGD:1561041
See related: EnsemblRapid:ENSRNOG00000003870 AllianceGenome:RGD:1561041
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adih; Ctrp2; RGD1561041
Summary: Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in regulation of lipid metabolic process. Predicted to act upstream of or within positive regulation of D-glucose import; positive regulation of MAPK cascade; and positive regulation of small molecule metabolic process. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. Orthologous to human C1QTNF2 (C1q and TNF related 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 117.5), Heart (RPKM 107.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (28443326..28460400)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (27941948..27958926)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (29067102..29084035)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The purpose of the current study was to investigate age-dependent effects of caloric restriction on the release of adiponectin, expression and activation of adiponectin-related signaling and on parameters of altered insulin sensitivity.
Title: Age-associated loss in adiponectin-activation by caloric restriction: lack of compensation by enhanced inducibility of adiponectin paralogs CTRP2 and CTRP7.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 2

Names: C1q and tumor necrosis factor related protein 2; adiponectin h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191918.1 → NP_001178847.1 complement C1q tumor necrosis factor-related protein 2 precursor

See identical proteins and their annotated locations for NP_001178847.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A3B0J1M6, A0A8I6AKQ7

Conserved Domains (2) summary

pfam01391
Location:76 → 130

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:160 → 284

C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

28443326..28460400

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086544.2 → XP_038942472.1 complement C1q tumor necrosis factor-related protein 2 isoform X1

UniProtKB/TrEMBL

A0A3B0J1M6, D3ZCS2

Related

ENSRNOP00000077656.2, ENSRNOT00000097801.2

Conserved Domains (2) summary

pfam00386
Location:151 → 275

C1q; C1q domain

pfam01391
Location:70 → 122

Collagen; Collagen triple helix repeat (20 copies)