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Drg2 developmentally regulated GTP binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497915, updated on 2-Nov-2024

Summary

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Official Symbol
Drg2provided by RGD
Official Full Name
developmentally regulated GTP binding protein 2provided by RGD
Primary source
RGD:1562380
See related
EnsemblRapid:ENSRNOG00000055309 AllianceGenome:RGD:1562380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562380
Summary
Predicted to enable GTPase activity and RNA binding activity. Predicted to be located in cytosol and nucleoplasm. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 152.4), Thymus (RPKM 146.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Drg2 in Genome Data Viewer
Location:
10q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45755072..45769493)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45255512..45269971)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46818412..46831308)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene GID complex subunit 4 Neighboring gene ribosomal protein S4, X-linked, pseudogene 6 Neighboring gene myosin XVA Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L17 like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Markolovic S, et al. Nat Chem Biol, 2018 Jul. PMID 29915238, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
developmentally-regulated GTP-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398843.1 → NP_001385772.1  developmentally-regulated GTP-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZWK0, A6HF46
    Related
    ENSRNOP00000084115.1, ENSRNOT00000104762.2
    Conserved Domains (1) summary
    COG1163
    Location:1 → 364
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45755072..45769493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087262.2 → XP_038943190.1  developmentally-regulated GTP-binding protein 2 isoform X1

    Conserved Domains (1) summary
    COG1163
    Location:1 → 283
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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