Pirt phosphoinositide-interacting regulator of transient receptor potential channels [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pirtprovided by RGD
Official Full Name: phosphoinositide-interacting regulator of transient receptor potential channelsprovided by RGD
Primary source: RGD:1565284
See related: EnsemblRapid:ENSRNOG00000063443 AllianceGenome:RGD:1565284
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565284
Summary: Predicted to enable phosphatidylinositol bisphosphate binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and transmembrane transporter binding activity. Predicted to be involved in phosphatidylinositol-mediated signaling and positive regulation of cation channel activity. Predicted to act upstream of or within behavioral response to pain and response to heat. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PIRT (phosphoinositide interacting regulator of transient receptor potential channels). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 34.9), Adrenal (RPKM 15.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (52112235..52127140)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (51613202..51628108)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (53466870..53485096)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cation channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphoinositide-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.