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Cntd1 cyclin N-terminal domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498001, updated on 17-Aug-2024

Summary

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Official Symbol
Cntd1provided by RGD
Official Full Name
cyclin N-terminal domain containing 1provided by RGD
Primary source
RGD:1564542
See related
AllianceGenome:RGD:1564542
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564542
Summary
Predicted to be involved in reciprocal meiotic recombination. Predicted to act upstream of or within spermatogenesis. Predicted to be active in site of double-strand break. Orthologous to human CNTD1 (cyclin N-terminal domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 113.3), Kidney (RPKM 45.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cntd1 in Genome Data Viewer
Location:
10q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86721692..86732074)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86221430..86231812)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89199988..89210369)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene ATP synthase membrane subunit K, pseudogene 2 Neighboring gene cytochrome C oxidase assembly factor 3 Neighboring gene beclin 1 Neighboring gene proteasome activator subunit 3 Neighboring gene amine oxidase, copper containing 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. Holloway JK, et al. J Cell Biol, 2014 Jun 9. PMID 24891606, Free PMC Article
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin N-terminal domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197217.1 → NP_001184146.1  cyclin N-terminal domain-containing protein 1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A096MKD3
    Conserved Domains (1) summary
    cd20541
    Location:50 → 175
    CYCLIN_CNTD1; cyclin box found in Cyclin N-terminal domain-containing protein 1 (CNTD1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86721692..86732074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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