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Gmnc geminin coiled-coil domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 498102, updated on 2-Nov-2024

Summary

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Official Symbol
Gmncprovided by RGD
Official Full Name
geminin coiled-coil domain containingprovided by RGD
Primary source
RGD:1563170
See related
EnsemblRapid:ENSRNOG00000038505 AllianceGenome:RGD:1563170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563170
Summary
Predicted to be involved in DNA replication; negative regulation of cell cycle; and regulation of DNA-templated DNA replication initiation. Predicted to act upstream of or within cilium assembly. Predicted to be active in nucleus. Orthologous to human GMNC (geminin coiled-coil domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 3.9), Brain (RPKM 3.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmnc in Genome Data Viewer
Location:
11q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (87339617..87352149)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (73836255..73847698)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (77237033..77247723)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene osteocrin Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 11 Neighboring gene uncharacterized LOC134481020 Neighboring gene uncharacterized LOC120095686 Neighboring gene interleukin 1 receptor accessory protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. Balestrini A, et al. Nat Cell Biol, 2010 May. PMID 20383140, Free PMC Article
  2. GemC1 controls multiciliogenesis in the airway epithelium. Arbi M, et al. EMBO Rep, 2016 Mar. PMID 26882546, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
geminin coiled-coil domain containing; geminin coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432508.1 → NP_001419437.1  geminin coiled-coil domain containing

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6G7A5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    87339617..87352149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248531.5 → XP_006248593.1  geminin coiled-coil domain-containing protein 1 isoform X1

    Related
    ENSRNOP00000080915.1, ENSRNOT00000120173.2
    Conserved Domains (1) summary
    pfam09457
    Location:89 → 130
    RBD-FIP; FIP domain

  2. XM_039088948.2 → XP_038944876.1  geminin coiled-coil domain-containing protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials