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Yeats2 YEATS domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498112, updated on 2-Nov-2024

Summary

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Official Symbol
Yeats2provided by RGD
Official Full Name
YEATS domain containing 2provided by RGD
Primary source
RGD:1566176
See related
EnsemblRapid:ENSRNOG00000023107 AllianceGenome:RGD:1566176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566176
Summary
Predicted to enable several functions, including TBP-class protein binding activity; histone reader activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of embryonic development; and regulation of tubulin deacetylation. Predicted to be located in mitotic spindle. Predicted to be part of ATAC complex and NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 105.9), Lung (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Yeats2 in Genome Data Viewer
Location:
11q23
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94247538..94333652, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80743134..80829253, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84330064..84595296, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352401 Neighboring gene MAP6 domain containing 1 Neighboring gene kelch-like family member 24 Neighboring gene transfer RNA threonine (anticodon AGU) 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. YEATS2 is a selective histone crotonylation reader. Zhao D, et al. Cell Res, 2016 May. PMID 27103431, Free PMC Article
  2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  3. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
  4. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
  5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
YEATS domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109057.2 → NP_001102527.1  YEATS domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001102527.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6JSC0, D3ZBV9
    Conserved Domains (2) summary
    PHA03247
    Location:342 → 653
    PHA03247; large tegument protein UL36; Provisional
    cd16907
    Location:209 → 332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  2. NM_001431681.1 → NP_001418610.1  YEATS domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6JSC0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    94247538..94333652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270713.1 → XP_063126783.1  YEATS domain-containing protein 2 isoform X3

  2. XM_063270710.1 → XP_063126780.1  YEATS domain-containing protein 2 isoform X1

  3. XM_063270711.1 → XP_063126781.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZPX3
    Related
    ENSRNOP00000080576.1, ENSRNOT00000112615.2

  4. XM_063270712.1 → XP_063126782.1  YEATS domain-containing protein 2 isoform X3

  5. XM_063270709.1 → XP_063126779.1  YEATS domain-containing protein 2 isoform X1

    Related
    ENSRNOP00000062371.3, ENSRNOT00000064212.3

  6. XM_063270714.1 → XP_063126784.1  YEATS domain-containing protein 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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