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Brat1 BRCA1-associated ATM activator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498150, updated on 14-Nov-2024

Summary

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Official Symbol
Brat1provided by RGD
Official Full Name
BRCA1-associated ATM activator 1provided by RGD
Primary source
RGD:1565146
See related
EnsemblRapid:ENSRNOG00000001236 AllianceGenome:RGD:1565146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brat1-ps1; RGD1565146
Summary
Predicted to be involved in several processes, including positive regulation of cell growth; positive regulation of protein phosphorylation; and response to ionizing radiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human BRAT1 (BRCA1 associated ATM activator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 47.7), Thymus (RPKM 47.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Brat1 in Genome Data Viewer
Location:
12q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19043004..19065686, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13928889..13951760, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16016062..16028534, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. So EY, et al. BMC Cancer, 2014 Jul 29. PMID 25070371, Free PMC Article
  2. The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR. So EY, et al. J Cancer Biol Res, 2013 Jul-Aug. PMID 25657994, Free PMC Article
  3. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. Aglipay JA, et al. J Biol Chem, 2006 Apr 7. PMID 16452482
  4. Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit. So EY, et al. Exp Ther Med, 2011 May. PMID 22977523, Free PMC Article
  5. Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. Low LH, et al. J Biol Chem, 2015 Mar 13. PMID 25631046, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BRCA1-associated ATM activator 1
Names
BRCA1-associated ATM activator 1, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431849.1 → NP_001418778.1  BRCA1-associated ATM activator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZSM9

  2. NM_001431850.1 → NP_001418779.1  BRCA1-associated ATM activator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZSM9

  3. NM_001431851.1 → NP_001418780.1  BRCA1-associated ATM activator 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  4. NM_001431852.1 → NP_001418781.1  BRCA1-associated ATM activator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A979

  5. NM_001431853.1 → NP_001418782.1  BRCA1-associated ATM activator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A979

  6. NM_001431854.1 → NP_001418783.1  BRCA1-associated ATM activator 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  7. NM_001431855.1 → NP_001418784.1  BRCA1-associated ATM activator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  8. NM_001431856.1 → NP_001418785.1  BRCA1-associated ATM activator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19043004..19065686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089962.2 → XP_038945890.1  BRCA1-associated ATM activator 1 isoform X1

    UniProtKB/TrEMBL
    A6K1R4, D3ZSM9
    Conserved Domains (1) summary
    sd00044
    Location:501 → 529
    HEAT; HEAT repeat [structural motif]

  2. XM_039089965.2 → XP_038945893.1  BRCA1-associated ATM activator 1 isoform X5

  3. XM_017598487.3 → XP_017453976.1  BRCA1-associated ATM activator 1 isoform X2

    Related
    ENSRNOP00000105329.1, ENSRNOT00000161004.1

  4. XM_006248968.4 → XP_006249030.1  BRCA1-associated ATM activator 1 isoform X1

    Conserved Domains (1) summary
    sd00044
    Location:501 → 529
    HEAT; HEAT repeat [structural motif]

  5. XM_003751133.3 → XP_003751181.1  BRCA1-associated ATM activator 1 isoform X1

    Related
    ENSRNOP00000059762.3, ENSRNOT00000064726.5
    Conserved Domains (1) summary
    sd00044
    Location:501 → 529
    HEAT; HEAT repeat [structural motif]

  6. XM_039089964.2 → XP_038945892.1  BRCA1-associated ATM activator 1 isoform X4

    Conserved Domains (1) summary
    sd00044
    Location:326 → 354
    HEAT; HEAT repeat [structural motif]

  7. XM_063271873.1 → XP_063127943.1  BRCA1-associated ATM activator 1 isoform X3

    Related
    ENSRNOP00000089150.1, ENSRNOT00000097546.2

  8. XM_063271874.1 → XP_063127944.1  BRCA1-associated ATM activator 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A979

  9. XM_063271875.1 → XP_063127945.1  BRCA1-associated ATM activator 1 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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