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Brat1 BRCA1-associated ATM activator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498150, updated on 14-Nov-2024

Summary

Official Symbol
Brat1provided by RGD
Official Full Name
BRCA1-associated ATM activator 1provided by RGD
Primary source
RGD:1565146
See related
EnsemblRapid:ENSRNOG00000001236 AllianceGenome:RGD:1565146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brat1-ps1; RGD1565146
Summary
Predicted to be involved in several processes, including positive regulation of cell growth; positive regulation of protein phosphorylation; and response to ionizing radiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human BRAT1 (BRCA1 associated ATM activator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 47.7), Thymus (RPKM 47.4) and 9 other tissues See more
Orthologs
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Genomic context

See Brat1 in Genome Data Viewer
Location:
12q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19043004..19065686, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13928889..13951760, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16016062..16028534, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion localization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
BRCA1-associated ATM activator 1
Names
BRCA1-associated ATM activator 1, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431849.1NP_001418778.1  BRCA1-associated ATM activator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZSM9
  2. NM_001431850.1NP_001418779.1  BRCA1-associated ATM activator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZSM9
  3. NM_001431851.1NP_001418780.1  BRCA1-associated ATM activator 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
  4. NM_001431852.1NP_001418781.1  BRCA1-associated ATM activator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A979
  5. NM_001431853.1NP_001418782.1  BRCA1-associated ATM activator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A979
  6. NM_001431854.1NP_001418783.1  BRCA1-associated ATM activator 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
  7. NM_001431855.1NP_001418784.1  BRCA1-associated ATM activator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
  8. NM_001431856.1NP_001418785.1  BRCA1-associated ATM activator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19043004..19065686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089962.2XP_038945890.1  BRCA1-associated ATM activator 1 isoform X1

    UniProtKB/TrEMBL
    A6K1R4, D3ZSM9
    Conserved Domains (1) summary
    sd00044
    Location:501529
    HEAT; HEAT repeat [structural motif]
  2. XM_039089965.2XP_038945893.1  BRCA1-associated ATM activator 1 isoform X5

  3. XM_017598487.3XP_017453976.1  BRCA1-associated ATM activator 1 isoform X2

    Related
    ENSRNOP00000105329.1, ENSRNOT00000161004.1
  4. XM_006248968.4XP_006249030.1  BRCA1-associated ATM activator 1 isoform X1

    Conserved Domains (1) summary
    sd00044
    Location:501529
    HEAT; HEAT repeat [structural motif]
  5. XM_003751133.3XP_003751181.1  BRCA1-associated ATM activator 1 isoform X1

    Related
    ENSRNOP00000059762.3, ENSRNOT00000064726.5
    Conserved Domains (1) summary
    sd00044
    Location:501529
    HEAT; HEAT repeat [structural motif]
  6. XM_039089964.2XP_038945892.1  BRCA1-associated ATM activator 1 isoform X4

    Conserved Domains (1) summary
    sd00044
    Location:326354
    HEAT; HEAT repeat [structural motif]
  7. XM_063271873.1XP_063127943.1  BRCA1-associated ATM activator 1 isoform X3

    Related
    ENSRNOP00000089150.1, ENSRNOT00000097546.2
  8. XM_063271874.1XP_063127944.1  BRCA1-associated ATM activator 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A979
  9. XM_063271875.1XP_063127945.1  BRCA1-associated ATM activator 1 isoform X6