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C12h7orf50 similar to human chromosome 7 open reading frame 50 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498154, updated on 2-Nov-2024

Summary

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Official Symbol
C12h7orf50provided by RGD
Official Full Name
similar to human chromosome 7 open reading frame 50provided by RGD
Primary source
RGD:1566418
See related
AllianceGenome:RGD:1566418
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C7orf50
Summary
Predicted to enable hormone activity. Predicted to be involved in negative regulation of cholesterol biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human C7orf50 (chromosome 7 open reading frame 50). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 42.1), Lung (RPKM 38.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See C12h7orf50 in Genome Data Viewer
Location:
12q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20298968..20402890)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15185728..15289042)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17277635..17380497)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 12 Neighboring gene zinc finger AN1-type containing 2A Neighboring gene RIKEN cDNA C130050O18 gene like Neighboring gene G protein-coupled estrogen receptor 1 Neighboring gene G protein-coupled receptor 146 Neighboring gene microRNA 339 Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1 Neighboring gene cytochrome c oxidase assembly factor COX19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cholesin; uncharacterized protein C7orf50 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025033.1 → NP_001020204.1  cholesin

    See identical proteins and their annotated locations for NP_001020204.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088429
    UniProtKB/Swiss-Prot
    Q5I0E3
    UniProtKB/TrEMBL
    A6K1V5
    Conserved Domains (1) summary
    pfam10180
    Location:103 → 163
    DUF2373; uncharacterized conserved protein (DUF2373)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    20298968..20402890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271577.1 → XP_063127647.1  uncharacterized protein C7orf50 homolog isoform X1

  2. XM_063271578.1 → XP_063127648.1  uncharacterized protein C7orf50 homolog isoform X3

  3. XM_063271582.1 → XP_063127652.1  uncharacterized protein C7orf50 homolog isoform X5

  4. XM_063271579.1 → XP_063127649.1  uncharacterized protein C7orf50 homolog isoform X4

  5. XM_063271581.1 → XP_063127651.1  uncharacterized protein C7orf50 homolog isoform X5

  6. XM_006248959.5 → XP_006249021.2  uncharacterized protein C7orf50 homolog isoform X2

    Conserved Domains (1) summary
    pfam10180
    Location:69 → 130
    DUF2373; Uncharacterized conserved protein (DUF2373)

  7. XM_063271580.1 → XP_063127650.1  uncharacterized protein C7orf50 homolog isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0E3.1 GenPept UniProtKB/Swiss-Prot:Q5I0E3

Gene LinkOut

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