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Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498233, updated on 2-Nov-2024

Summary

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Official Symbol
Lgr6provided by RGD
Official Full Name
leucine-rich repeat-containing G protein-coupled receptor 6provided by RGD
Primary source
RGD:1560339
See related
EnsemblRapid:ENSRNOG00000005093 AllianceGenome:RGD:1560339
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560339
Summary
Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in several processes, including axon guidance; negative chemotaxis; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within bone regeneration and cell population proliferation. Predicted to be located in vesicle. Orthologous to human LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 53.6), Lung (RPKM 11.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lgr6 in Genome Data Viewer
Location:
13q13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48976193..49095870, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46424382..46544074, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51811904..51931193, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 4 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene uncharacterized LOC120096252 Neighboring gene protein tyrosine phosphatase, receptor type, V Neighboring gene protein tyrosine phosphatase, non-receptor type 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lgr6 marks nail stem cells and is required for digit tip regeneration. Lehoczky JA, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26460010, Free PMC Article
  2. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. Gong X, et al. PLoS One, 2012. PMID 22615920, Free PMC Article
  3. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone regeneration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tissue regeneration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427357.2 → NP_001414286.1  leucine-rich repeat-containing G-protein coupled receptor 6 precursor

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    D3ZJU9
    Related
    ENSRNOP00000006969.4, ENSRNOT00000006969.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    48976193..49095870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091316.2 → XP_038947244.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

    UniProtKB/TrEMBL
    A6ICD4
    Related
    ENSRNOP00000110269.1, ENSRNOT00000135242.1
    Conserved Domains (5) summary
    smart00013
    Location:34 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:60 → 429
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:330 → 344
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:70 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    cd15362
    Location:520 → 796
    7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs
Nucleotide Protein Strain
Heading Accession and Version

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