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Srp72 signal recognition particle 72 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498351, updated on 2-Nov-2024

Summary

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Symbol
Srp72provided by RGD
Full Name
signal recognition particle 72provided by RGD
Primary source
RGD:1564787
See related
EnsemblRapid:ENSRNOG00000002100 AllianceGenome:RGD:1564787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 7S RNA binding activity; TPR domain binding activity; and signal recognition particle binding activity. Predicted to contribute to ribosome binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 143.9), Kidney (RPKM 143.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srp72 in Genome Data Viewer
Location:
14p11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31522424..31549978, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31168175..31195717, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33447583..33453788, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule associated protein 2 like Neighboring gene uncharacterized LOC134481837 Neighboring gene uncharacterized LOC120096735 Neighboring gene ARF like GTPase 9 Neighboring gene uncharacterized LOC120096737 Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia. Kirwan M, et al. Am J Hum Genet, 2012 May 4. PMID 22541560, Free PMC Article
  2. Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. Menichelli E, et al. J Mol Biol, 2007 Mar 16. PMID 17254600
  3. Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Becker MM, et al. Nucleic Acids Res, 2017 Jan 9. PMID 27899666, Free PMC Article
  4. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Yoshida M, et al. Mol Pharmacol, 2008 Mar. PMID 18089836
  5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 7S RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables signal recognition particle binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle subunit SRP72
Names
signal recognition particle 72 kDa protein
signal recognition particle 72 kDa protein-like
signal recognition particle 72kDa
signal recognition particle subunit SRP72-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170601.1 → NP_001164072.1  signal recognition particle subunit SRP72

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6AW91, F7FFH0
    Related
    ENSRNOP00000082438.1, ENSRNOT00000104763.2
    Conserved Domains (7) summary
    sd00006
    Location:176 → 204
    TPR; TPR repeat [structural motif]
    pfam08492
    Location:531 → 584
    SRP72; SRP72 RNA-binding domain
    pfam12895
    Location:57 → 134
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:175 → 255
    TPR_12; Tetratricopeptide repeat
    pfam14559
    Location:351 → 414
    TPR_19; Tetratricopeptide repeat
    pfam17004
    Location:36 → 157
    SRP_TPR_like; Putative TPR-like repeat
    cl23899
    Location:344 → 523
    Spore_YpjB; Sporulation protein YpjB (SpoYpjB)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    31522424..31549978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092285.2 → XP_038948213.1  signal recognition particle subunit SRP72 isoform X1

    UniProtKB/TrEMBL
    D4A7R0, F7FFH0
    Related
    ENSRNOP00000002862.5, ENSRNOT00000002862.8
    Conserved Domains (4) summary
    TIGR02917
    Location:25 → 460
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:176 → 204
    TPR; TPR repeat [structural motif]
    pfam17004
    Location:36 → 157
    SRP_TPR_like; Putative TPR-like repeat
    pfam08492
    Location:489 → 541
    SRP72; SRP72 RNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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